PARD3B Antibody (E-9): sc-398761
- PARD3B Antibody (E-9) is a mouse monoclonal IgG1 κ PARD3B antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 86-117 near the N-terminus of PARD3B of human origin
- PARD3B Antibody (E-9) is recommended for detection of PARD3B of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-PARD3B Antibody (E-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PARD3B Antibody (E-9) for WB and IHC(P) applications. These reagents are now offered in bundles with PARD3B Antibody (E-9) (see ordering information below).
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PARD3B Antibody (E-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects PARD3B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-PARD3B antibody (E-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PARD3B, also known as par-3 partitioning defective 3 homolog B, plays a crucial role in maintaining cellular asymmetry, which is essential for proper development of multicellular organisms. PARD3B is primarily localized at cell junctions, where PARD3B interacts with other proteins such as ZO-1 (zona occludens protein 1) to facilitate formation of epithelial tight junctions. PARD3B is expressed in various tissues, with highest levels found in skeletal muscle, lung, and kidney, and moderate expression in pancreas, brain, heart, liver, and placenta. PARD3B consists of 1,205 amino acids and features three PDZ (DHR) domains, which are critical for protein-protein interactions. PARD3B exists in five alternatively spliced isoforms and is encoded by a gene located on human chromosome 2q33.2, highlighting PARD3B′s importance in cellular processes and potential implications in developmental biology and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PARD3B Antibody (E-9) References:
- A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. | Hadano, S., et al. 2001. Nat Genet. 29: 166-73. PMID: 11586298
- Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties. | Gao, L., et al. 2002. Gene. 294: 99-107. PMID: 12234671
- PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions. | Kohjima, M., et al. 2002. Biochem Biophys Res Commun. 299: 641-6. PMID: 12459187
- Identification of three novel Smad binding proteins involved in cell polarity. | Warner, DR., et al. 2003. FEBS Lett. 539: 167-73. PMID: 12650946
- Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. | Jin, J., et al. 2004. Curr Biol. 14: 1436-50. PMID: 15324660
- Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. | Izaki, T., et al. 2006. Biochem Biophys Res Commun. 341: 1001-6. PMID: 16458856
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PARD3B Antibody (E-9) | sc-398761 | 200 µg/ml | $322.00 | |||
PARD3B Antibody (E-9): m-IgG Fc BP-HRP Bundle | sc-530920 | 200 µg Ab; 10 µg BP | $361.00 | |||
PARD3B Antibody (E-9): m-IgGκ BP-HRP Bundle | sc-524475 | 200 µg Ab, 40 µg BP | $361.00 | |||
PARD3B Antibody (E-9): m-IgG1 BP-HRP Bundle | sc-544318 | 200 µg Ab; 20 µg BP | $361.00 | |||
PARD3B Antibody (E-9) AC | sc-398761 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PARD3B Antibody (E-9) HRP | sc-398761 HRP | 200 µg/ml | $322.00 | |||
PARD3B Antibody (E-9) FITC | sc-398761 FITC | 200 µg/ml | $336.00 | |||
PARD3B Antibody (E-9) PE | sc-398761 PE | 200 µg/ml | $349.00 | |||
PARD3B Antibody (E-9) Alexa Fluor® 488 | sc-398761 AF488 | 200 µg/ml | $364.00 | |||
PARD3B Antibody (E-9) Alexa Fluor® 546 | sc-398761 AF546 | 200 µg/ml | $364.00 | |||
PARD3B Antibody (E-9) Alexa Fluor® 594 | sc-398761 AF594 | 200 µg/ml | $364.00 | |||
PARD3B Antibody (E-9) Alexa Fluor® 647 | sc-398761 AF647 | 200 µg/ml | $364.00 | |||
PARD3B Antibody (E-9) Alexa Fluor® 680 | sc-398761 AF680 | 200 µg/ml | $364.00 | |||
PARD3B Antibody (E-9) Alexa Fluor® 790 | sc-398761 AF790 | 200 µg/ml | $364.00 | |||
PARD3B (E-9) Neutralizing Peptide | sc-398761 P | 100 µg/0.5 ml | $69.00 |