PAR-6β Activators
Partitioning defective-6 beta (PAR-6β) is a pivotal protein that plays an integral role in the establishment and maintenance of cellular polarity. Cellular polarity is a fundamental aspect of cell biology, essential for numerous physiological processes, including tissue organization, cell migration, and the development of cellular structures. PAR-6β operates as part of a protein complex that orchestrates these processes by interacting with various molecular partners to transmit signals that delineate cellular orientation and structure. The precise modulation of PAR-6β expression is crucial for its function, as it ensures the correct spatial and temporal activation of cell polarity pathways. A deeper understanding of the mechanisms that govern the expression of PAR-6β can illuminate the intricate web of cellular signaling and gene regulation necessary for the maintenance of cellular architecture and function.
Research into the chemical landscape of cellular signaling has identified several non-proteinaceous compounds that could potentially serve as activators for the expression of proteins like PAR-6β. Compounds like retinoic acid and forskolin demonstrate the capacity to upregulate gene expression by engaging with nuclear receptors or elevating intracellular secondary messengers, respectively, which could lead to an increase in PAR-6β transcription. Other compounds, such as histone deacetylase inhibitors like Trichostatin A and Sodium Butyrate, might enhance the accessibility of the PAR-6β gene to transcriptional machinery, thereby stimulating its expression. Moreover, molecules like lithium chloride, which has been shown to influence the Wnt signaling pathway, could similarly stimulate the expression of PAR-6β by altering the expression of genes involved in cell polarity. Understanding how these activators can influence PAR-6β expression is essential for dissecting the regulatory networks that control cell polarity and for appreciating the complexity of cellular signaling in maintaining the sophisticated order within living organisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may upregulate PAR-6β expression by activating nuclear receptors that bind retinoic acid response elements in the promoters of genes involved in cellular differentiation, potentially including PAR-6β. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate could stimulate PAR-6β expression through its antioxidative properties, leading to the activation of defensive gene expression pathways against oxidative stress that may encompass PAR-6β. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin may increase PAR-6β levels by elevating cAMP, which subsequently activates PKA, leading to the phosphorylation of transcription factors specifically tasked with boosting the transcription of genes like PAR-6β. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride could induce PAR-6β expression by inhibiting GSK-3β, thereby allowing the stabilization and accumulation of β-catenin, which could initiate transcription of Wnt target genes including PAR-6β. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine might promote PAR-6β expression by inducing global DNA demethylation, thereby relieving repression of gene transcription and potentially enabling the activation of PAR-6β expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A may enhance PAR-6β transcription by preventing histone deacetylation, leading to a less condensed chromatin structure and a subsequent increase in the accessibility of the PAR-6β gene to transcription machinery. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone could stimulate the expression of PAR-6β by activating glucocorticoid receptors that might interact with glucocorticoid response elements upstream of the PAR-6β gene. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate may enhance PAR-6β expression through its inhibition of histone deacetylases, which could result in an open chromatin conformation and increased transcriptional activity of the PAR-6β gene. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may stimulate PAR-6β expression by exerting anti-inflammatory effects that lead to the suppression of NF-κB pathway, which indirectly might result in the upregulation of genes governing cell polarity such as PAR-6β. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could induce PAR-6β expression by activating SIRT1, leading to deacetylation of transcription factors or coactivators involved in the transcription of cell polarity-related genes including PAR-6β. | ||||||