Date published: 2025-9-12

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PAPD4 Activators

PAPD4 Activators are a set of chemicals that facilitate the functional activity of PAPD4 through their influence on various biochemical signaling pathways. Forskolin, by increasing adenylate cyclase activity and thereby raising cAMP levels, indirectly supports the activity of PAPD4 through cAMP-dependent PKA, which can phosphorylate proteins and alter signaling pathways that PAPD4 is a part of. Genistein, as a tyrosine kinase inhibitor, reduces competitive phosphorylation events, potentially allowing for enhanced PAPD4 activity within those pathways. Sphingosine-1-phosphate and Thapsigargin both act on lipid and calcium signaling, respectively, with Sphingosine-1-phosphate activating its receptors and modulating downstream signaling that affects PAPD4 activity, and Thapsigargin raising intracellular calcium to activate calcium-dependent signaling pathways where PAPD4 operates. PMA's activation of PKC and the PI3K inhibitors LY294002 and Wortmannin can indirectly promote PAPD4's activity by shifting the balance of cellular signaling in its favor, as these molecules alter the phosphorylation landscape that PAPD4 is likely involved in.

The activity of PAPD4 is further assisted by compounds that target the MAPK signaling cascade. SB203580 and U0126 work by inhibiting p38 and MEK1/2, respectively, which might lead to a compensatory activation of pathways involving PAPD4, indirectly enhancing its functional role. The ionophore A23187 facilitates PAPD4's activity by elevating intracellular calcium levels and thus activating calcium-dependent signaling pathways crucial for PAPD4's role in the cell. Meanwhile, Staurosporine, by broadly inhibiting protein kinases, might lead to the selective activation of pathways involving PAPD4 by reducing the inhibition exerted by certain kinases on PAPD4-related processes. Lastly, Epigallocatechin gallate (EGCG) serves to enhance PAPD4 activity by inhibiting kinases that may negatively regulate pathways that PAPD4 is part of, thus providing a less antagonistic environment for PAPD4's functional operations.

SEE ALSO...

Items 1 to 10 of 11 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Forskolin activates adenylate cyclase, increasing cAMP levels, which in turn can enhance PAPD4 activity by promoting cAMP-dependent protein kinase A (PKA) signaling pathways that PAPD4 is involved in.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

Genistein is a tyrosine kinase inhibitor that by preventing tyrosine phosphorylation can enhance signaling pathways that are positively regulated by PAPD4.

D-erythro-Sphingosine-1-phosphate

26993-30-6sc-201383
sc-201383D
sc-201383A
sc-201383B
sc-201383C
1 mg
2 mg
5 mg
10 mg
25 mg
$162.00
$316.00
$559.00
$889.00
$1693.00
7
(1)

This lipid signaling molecule can activate sphingosine-1-phosphate receptors, which through downstream effects, can lead to the activation of pathways involving PAPD4.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$94.00
$349.00
114
(2)

Thapsigargin raises intracellular calcium levels which can trigger calcium-dependent signaling mechanisms, indirectly enhancing the activity of PAPD4.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

PMA activates protein kinase C (PKC), which can phosphorylate and thereby modulate pathways that PAPD4 is a part of, leading to its enhanced activity.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002 is a PI3K inhibitor that can shift signaling towards pathways that PAPD4 is involved in, thereby indirectly enhancing its activity.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Wortmannin is another PI3K inhibitor that, similar to LY294002, can skew cellular signaling pathways in a manner that could enhance the activity of PAPD4.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

SB203580 is a p38 MAP kinase inhibitor which can redirect cellular signaling to pathways where PAPD4 may play a role, indirectly enhancing its activity.

A23187

52665-69-7sc-3591
sc-3591B
sc-3591A
sc-3591C
1 mg
5 mg
10 mg
25 mg
$54.00
$128.00
$199.00
$311.00
23
(1)

A calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent signaling pathways that enhance PAPD4 activity.

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$150.00
$388.00
113
(4)

A broad-spectrum protein kinase inhibitor that can inadvertently enhance the activity of PAPD4 by inhibiting kinases that negatively regulate pathways involving PAPD4.