pan-Cytokeratin Inhibitors
Pan-Cytokeratin Inhibitors are a chemical class of compounds designed to selectively target and modulate the activity of cytokeratins, a family of intermediate filament proteins found in epithelial cells. Cytokeratins are integral components of the cytoskeleton, providing structural support and integrity to epithelial tissues. Structurally, cytokeratins are characterized by their filamentous nature, composed of both acidic and basic subunits. These proteins are categorized into various types based on their molecular weight and sequence homology, and they play a crucial role in maintaining cellular shape, stability, and resistance to mechanical stress.
The functions of cytokeratins extend to the formation of the cytoskeleton in epithelial cells, contributing to tissue strength and flexibility. They also play a role in cellular adhesion, which is essential for the integrity and function of epithelial tissues. In addition to their structural functions, cytokeratins are used as markers in diagnostic pathology to identify the origin and differentiation state of epithelial cells in tissues. Pan-Cytokeratin Inhibitors are designed as small molecules or compounds engineered to interfere with the assembly, stability, or function of cytokeratin filaments within cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-Fluorouracil is an antimetabolite that might reduce the expression of cytokeratin by incorporating into RNA and DNA, leading to the disruption of nucleic acid metabolism and synthesis, which in turn affects the production of various proteins, including cytokeratins. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin binds to DNA, causing DNA damage and inhibiting DNA synthesis. By affecting DNA replication, cisplatin might indirectly suppress the transcription and translation of various genes, including those encoding cytokeratins. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib is an EGFR inhibitor. The EGFR pathway can upregulate cytokeratin expression in certain cells. By inhibiting this pathway, gefitinib might reduce cytokeratin expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can induce cell differentiation. In some cellular contexts, differentiation processes can lead to reduced cytokeratin expression as cells switch their protein expression profiles. | ||||||
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $31.00 $84.00 $147.00 | 3 | |
Sulindac might influence the expression of various proteins in the cell, including cytokeratins. Its mechanism might be related to its effects on cyclooxygenase pathways and downstream signaling events. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to modulate the expression of various proteins in the cell. It might affect cytokeratin expression through its anti-inflammatory and antioxidant properties, which can influence multiple cellular pathways. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate is an antimetabolite that affects DNA synthesis. By disrupting DNA replication and repair, it can potentially reduce the transcription and translation of various genes, including those for cytokeratins. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. The mTOR pathway plays a role in protein synthesis in the cell. By inhibiting this pathway, rapamycin might reduce the synthesis of various proteins, including cytokeratins. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor. Kinases play roles in various signaling pathways that can regulate protein expression. By inhibiting these kinases, staurosporine might influence the expression of cytokeratins. | ||||||
Salinomycin | 53003-10-4 | sc-253530 sc-253530C sc-253530A sc-253530B | 5 mg 10 mg 25 mg 100 mg | $159.00 $236.00 $398.00 $465.00 | 1 | |
Salinomycin might affect multiple cellular pathways, leading to a potential decrease in the expression of various proteins, including cytokeratins. | ||||||