pan-Cytokeratin Antibody (C11): sc-8018

pan-Cytokeratin Antibody (C11) is a mouse monoclonal IgG1 kappa light chain antibody that detects pan-Cytokeratin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). pan-Cytokeratin (C11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cytokeratins, which are a diverse group of intermediate filament proteins, are crucial for maintaining the structural integrity of epithelial cells and are expressed in pairs within keratinized and non-keratinized epithelial tissues. The importance of cytokeratins extends to their role in cellular differentiation and tissue specialization, making these proteins valuable markers for identifying and characterizing malignant tumors. For instance, specific cytokeratins such as cytokeratin 10 and cytokeratin 13 are highly expressed in certain squamous cell carcinomas, while cytokeratin 18 is predominantly found in adenocarcinomas and basal cell carcinomas. anti-pan-Cytokeratin antibody (C11) recognition of these proteins enhances research utility in cancer research and diagnostics, providing insights into tumor biology and aiding in the assessment of tissue differentiation.

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pan-Cytokeratin Antibody (C11) References:

1. K15 expression implies lateral differentiation within stratified epithelial basal cells.  |  Porter, RM., et al. 2000. Lab Invest. 80: 1701-10. PMID: 11092530
2. An investigation of cytokeratin expression in skin epithelial cysts and some uncommon types of cystic tumours using chain-specific antibodies.  |  Broekaert, D., et al. 1990. Arch Dermatol Res. 282: 383-91. PMID: 1701984
3. Human lung tumours: a correlation of antigenic profile with histological type.  |  Gatter, KC., et al. 1985. Histopathology. 9: 805-23. PMID: 2414203
4. The characterization of two monoclonal anti-keratin antibodies and their use in the study of epithelial disorders.  |  Pulford, KA., et al. 1985. Histopathology. 9: 825-40. PMID: 2414204
5. Pan-cytokeratin markers for rapid frozen section immunocytochemistry from head and facial Mohs cases of basal cell carcinoma: a comparison and evaluation to determine the marker of choice.  |  Orchard, GE., et al. 2015. Br J Biomed Sci. 72: 61-6. PMID: 26126321
6. [Evaluation of immunohistochemistry pan-cytokeratin and Victoria blue double staining in the assessment of pT3 and pT4a colorectal cancer staging].  |  Xie, LW., et al. 2023. Zhonghua Bing Li Xue Za Zhi. 52: 1034-1036. PMID: 37805397
7. Evaluation of a new tumor marker for cytokeratin 8 and 18 fragments in healthy individuals and prostate cancer patients.  |  Silén, A., et al. 1994. Prostate. 24: 326-32. PMID: 7516071
8. A novel IRMA and ELISA for quantifying cytokeratin 8 and 18 fragments in the sera of healthy individuals and cancer patients.  |  Silén, A., et al. 1995. Scand J Clin Lab Invest. 55: 153-61. PMID: 7545308
9. Cytokeratin expression in normal and (pre)malignant head and neck epithelia: an overview.  |  van der Velden, LA., et al. 1993. Head Neck. 15: 133-46. PMID: 7680025
10. Serum and tissue distribution of a fragment of cytokeratin 19 (cyfra 21-1) in lung cancer patients.  |  Quillien, V., et al. 1995. Anticancer Res. 15: 2857-63. PMID: 8669879
11. Functional inactivation of p53 by antisense RNA induces invasive ability of lung carcinoma cells and downregulates cytokeratin synthesis.  |  Mukhopadhyay, T. and Roth, JA. 1996. Anticancer Res. 16: 1683-9. PMID: 8712687
12. Cytokeratin expression, fibrillar organization, and subtle function in liver cells.  |  Marceau, N. and Loranger, A. 1995. Biochem Cell Biol. 73: 619-25. PMID: 8714681

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-pan-Cytokeratin Antibody (C11) has 164 citations in a variety of scientific publications.

Primary antibodies like Anti-pan-Cytokeratin Antibody (C11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

pan-Cytokeratin Antibody (C11) Specifications

Alternate Product Name: Cytokeratin

Product Clone Name: C11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: pan-Cytokeratin

Epitope Species: human

Product Reactivity/Detection: Cytokeratin 4, 5, 6, 8, 10, 13 and 18

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 164 citations in various scientific publications

Available Conjugates/Forms for pan-Cytokeratin Antibody (C11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin