Pallidin Inhibitors
Pallidin inhibitors are chemical entities that can curtail the functional activity of Pallidin, a protein involved in various signaling processes. These inhibitors range from broad-spectrum protein kinase inhibitors like Staurosporine, which can reduce the activity of Pallidin by broadly inhibiting kinases involved in these signaling pathways, to more pathway-specific inhibitors such as U0126, a MEK inhibitor. The inhibition of MEK by U0126 can indirectly suppress the MAPK/ERK signaling events that Pallidin participates in, thereby decreasing its functional activity. Other inhibitors influencing the same pathway include PD98059, which operates in a similar manner to U0126 in attenuating Pallidin's functional activity.
Similarly, inhibiting the PI3K/Akt pathway, another critical cascade associated with Pallidin, are LY294002 and Wortmannin. Both are potent inhibitors of PI3K, and their inhibition of this kinase can dampen the signaling cascade in which Pallidin operates, thereby indirectly downregulating its functional activity. Other inhibitors that can indirectly lead to the decreased functional activity of Pallidin include Rapamycin, an mTORinhibitor, and Genistein, a broad inhibitor of protein tyrosine kinases. Rapamycin's inhibition
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of PI3K, a key player in the Akt signaling pathway. This pathway has been implicated in the function of Pallidin. By inhibiting PI3K, LY294002 can dampen the signaling cascade in which Pallidin operates, thereby indirectly downregulating its functional activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor known to dampen various signaling pathways, including those where Pallidin is a crucial component. By broadly inhibiting these kinases, Staurosporine can reduce the activity of Pallidin. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of PI3K. Similar to LY294002, it can inhibit the Akt pathway and, consequently, reduce the functional activity of Pallidin. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an inhibitor of mTOR, a central regulator of cell growth and survival. As the mTOR pathway interacts with the Akt pathway, where Pallidin is involved, Rapamycin can indirectly lead to the decreased functional activity of Pallidin. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK, a pathway involved in cellular responses to stress and inflammation. Pallidin is implicated in this pathway, and its inhibition by SB203580 can indirectly affect Pallidin's function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor that hinders the JNK signaling pathway. This pathway is associated with cellular responses to stress and inflammation, where Pallidin plays a role. By inhibiting JNK, SP600125 can indirectly dampen Pallidin's functional activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a broad inhibitor of protein tyrosine kinases which are key components in numerous signaling pathways. Its inhibition can indirectly affect the signaling events in which Pallidin is involved, thereby reducing its functional activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an inhibitor of the Src family of kinases, which play roles in various signaling cascades. By inhibiting these kinases, PP2 can indirectly attenuate the signaling processes that Pallidin is involved in. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is an inhibitor of ROCK, a kinase involved in cell shape and movement. Its inhibition can indirectly affect the signaling events that Pallidin regulates, leading to decreased functional activity of Pallidin. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor that dampens the MAPK/ERK pathway. By inhibiting this pathway, PD98059 can decrease the functional activity of Pallidin, which is known to be involved in this pathway. | ||||||