p53R2 Activators

Common p53R2 Activators include, but are not limited to Doxorubicin hydrochloride CAS 25316-40-9, Fluorouracil CAS 51-21-8, Camptothecin CAS 7689-03-4, Etoposide (VP-16) CAS 33419-42-0 and Cisplatin CAS 15663-27-1.

p53R2 (also known as RRM2B) is a ribonucleotide reductase that plays a crucial role in DNA repair and mitochondrial DNA synthesis. Its expression is p53-dependent and can be induced under DNA damage or oxidative stress. P53R2 Activators is a class of compounds or molecules that influence the activity of the p53R2 protein, also known as ribonucleotide reductase subunit p53R2. This protein is a crucial component in the regulation of nucleotide metabolism and DNA repair, particularly in the context of cell cycle progression and DNA synthesis. P53R2 is a part of the larger family of ribonucleotide reductases (RNRs), which are enzymes responsible for converting ribonucleotides into deoxyribonucleotides, the building blocks of DNA. The activation of p53R2 is vital for maintaining genomic stability and ensuring the availability of the necessary precursors for DNA replication and repair.

P53R2 Activators exert their effects by modulating the activity or expression of p53R2. The p53R2 protein itself is regulated by the tumor suppressor protein p53, which is often referred to as the "guardian of the genome." P53R2 activation is typically observed in response to DNA damage or cellular stress, and it plays a critical role in supplying deoxyribonucleotides for DNA repair processes. By enhancing the activation of p53R2, these activators can impact DNA repair and replication processes, contributing to cell survival and genomic integrity. Understanding the regulation of p53R2 and the role of p53R2 Activators is essential for advancing our knowledge of DNA repair mechanisms and their implications in various biological processes, including cancer development and responses to genotoxic stress.