p53R2 Inhibitors
Common p53R2 Inhibitors include, but are not limited to 2'-Deoxy-2',2'-difluorocytidine CAS 95058-81-4, Hydroxyurea CAS 127-07-1, Cisplatin CAS 15663-27-1, Doxorubicin CAS 23214-92-8 and Fluorouracil CAS 51-21-8.
p53R2 inhibitors pertain to a chemical class that specifically targets the p53-inducible ribonucleotide reductase small subunit 2 (p53R2) protein. This protein is involved in DNA synthesis and repair processes within the cell, particularly during times of DNA damage and stress. p53R2 is regulated by the tumor suppressor protein p53, which is a crucial factor in maintaining genomic integrity and stopping the propagation of damaged DNA.
By inhibiting p53R2, these compounds disrupt DNA replication and repair mechanisms, which could influence the cell's ability to accurately replicate its genetic material and respond to various forms of DNA damage. Inhibition of p53R2 may trigger specific cellular responses, leading to alterations in cell cycle progression and survival mechanisms. Such inhibitors provide a valuable tool for researchers to elucidate the role of p53R2 in DNA maintenance, replication, and repair pathways, aiding in a deeper understanding of cellular processes related to genomic stability and contributing to the development of strategies for addressing DNA-related diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
A nucleoside analog that might impact ribonucleotide reductase activity, affecting DNA synthesis. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
An inhibitor of ribonucleotide reductase that could potentially affect p53R2 function and nucleotide metabolism. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
A chemotherapeutic agent that might indirectly affect p53R2 expression or activity through DNA damage responses. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
An anthracycline antibiotic that might modulate p53R2 expression and impact nucleotide metabolism in cells. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
A nucleoside analog that could potentially affect p53R2 expression and nucleotide metabolism in cancer cells. | ||||||
Carboplatin | 41575-94-4 | sc-202093 sc-202093A | 25 mg 100 mg | $48.00 $135.00 | 14 | |
A platinum-based chemotherapy drug that might indirectly affect p53R2 function through DNA damage responses. | ||||||
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $150.00 $263.00 $518.00 $731.00 $1461.00 | 1 | |
A nucleoside analog that could impact p53R2 expression and nucleotide metabolism in certain cellular contexts. | ||||||
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid | 137281-23-3 | sc-479733 | 250 mg | $330.00 | 1 | |
An antifolate chemotherapy drug that might indirectly affect p53R2 function through nucleotide metabolism pathways. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
A topoisomerase inhibitor that might modulate p53R2 expression and function through DNA damage responses. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
A folate antagonist that might impact p53R2 expression and nucleotide metabolism in certain cellular contexts. | ||||||