p47-phox Inhibitors
p47-phox Inhibitors represent a distinct chemical class of compounds designed to selectively target and modulate the activity of the p47-phox protein. p47-phox is a vital component of the NADPH oxidase (NOX) enzyme complex, which plays a crucial role in the generation of reactive oxygen species (ROS) within immune cells, particularly phagocytes like neutrophils and macrophages. Structurally, p47-phox is a cytosolic protein that is essential for the activation of the NOX complex during the immune response. This activation process involves the translocation of p47-phox to the cell membrane, where it interacts with other NOX subunits and initiates ROS production as part of the host defense against pathogens.
The functions of p47-phox and the NOX complex are intricately linked to immune responses and cellular signaling. During infections or inflammatory events, p47-phox undergoes phosphorylation and conformational changes, allowing it to bind to other NOX subunits, such as gp91-phox and p22-phox, leading to the assembly of the active NOX complex. This complex then facilitates the controlled production of ROS, which are essential for microbial killing and signaling processes. p47-phox Inhibitors are typically designed as small molecules or compounds that can interfere with the activation and translocation of p47-phox, thereby modulating the activity of the NOX complex and ROS production.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Diphenyleneiodonium chloride | 4673-26-1 | sc-202584E sc-202584 sc-202584D sc-202584A sc-202584B sc-202584C | 10 mg 25 mg 50 mg 100 mg 250 mg 500 mg | $151.00 $136.00 $317.00 $405.00 $944.00 $1837.00 | 24 | |
DPI inhibits flavoenzymes and can block NADPH oxidase activity, potentially affecting p47-phox function. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Baicalein can inhibit the activation of NADPH oxidase, potentially by affecting p47-phox phosphorylation or translocation. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $33.00 $136.00 $458.00 | 5 | |
Ebselen is an antioxidant that can inhibit NADPH oxidase activity, potentially affecting p47-phox function. | ||||||
MCI-186 | 89-25-8 | sc-200806 sc-200806A | 5 g 100 g | $20.00 $32.00 | 10 | |
Edaravone, a free radical scavenger, can inhibit NADPH oxidase activity, which might impact p47-phox function. | ||||||
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $109.00 $384.00 $2190.00 | 3 | |
NDGA has antioxidant properties and can inhibit p47-phox translocation, thus reducing NADPH oxidase activation. | ||||||
2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione | sc-501137 | 25 mg | $380.00 | |||
GKT137831 is a direct inhibitor of NADPH oxidase that can affect the function of components like p47-phox. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol has anti-inflammatory properties and can inhibit NADPH oxidase activation, which may influence p47-phox function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has antioxidant properties and can inhibit p47-phox translocation, reducing NADPH oxidase activation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties that can inhibit p47-phox function and NADPH oxidase activation. | ||||||