p47-phox Activators
p47-phox Activators offer diverse mechanisms that converge on the augmentation of the functional activity of p47-phox. Apocynin and DPI operate in concert to inhibit NADPH oxidase, thereby indirectly activating p47-phox through the restraint of reactive oxygen species (ROS) production and the alleviation of inhibitory feedback mechanisms. This orchestrated action emphasizes the intricacies of modulating p47-phox in the context of redox balance. PMA, with a direct modulatory approach, activates p47-phox by instigating its phosphorylation through the mediation of protein kinase C (PKC). Meanwhile, Auranofin exerts its influence indirectly by disrupting redox equilibrium, thereby activating p47-phox through the inhibition of thioredoxin reductase, further underscoring the multifaceted nature of p47-phox regulation. Genistein and Bisindolylmaleimide I emerge as direct enhancers of p47-phox activity, exhibiting their impact by forestalling inhibitory phosphorylation through the inhibition of tyrosine kinase and PKC, respectively.
Angiotensin II, operating through its receptor, activates p47-phox, thereby inducing heightened expression and translocation of the protein. This signifies a distinctive mode of activation involving receptor-mediated cascades influencing p47-phox functionality. Thioridazine, an indirect activator, modulates p47-phox by inhibiting calmodulin and disrupting calcium signaling, illustrating the diverse repertoire of pathways impinging on p47-phox activation. Pyocyanin engages in direct activation of p47-phox by catalyzing the generation of ROS, thereby directly influencing the functional activity of p47-phox. In parallel, Resveratrol, an indirect activator, shapes p47-phox activity by modulating redox-sensitive pathways through the activation of sirtuins, adding another layer to the intricate regulatory mechanisms governing p47-phox. Finally, Go6976 and Vanadyl sulfate contribute to the indirect activation of p47-phox. Go6976 inhibits PKC, indirectly influencing p47-phox, while Vanadyl sulfate promotes ROS production, adding another dimension to the spectrum of modulators converging on p47-phox activation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Apocynin | 498-02-2 | sc-203321 sc-203321A sc-203321B sc-203321C | 1 g 10 g 100 g 500 g | $27.00 $68.00 $116.00 $360.00 | 74 | |
Apocynin, a known NADPH oxidase inhibitor, indirectly enhances p47-phox activity. By preventing ROS production, it relieves the inhibitory feedback on p47-phox, leading to sustained p47-phox activation and increased participation in NADPH oxidase-mediated signaling events. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), directly enhancing p47-phox phosphorylation. Phosphorylated p47-phox exhibits increased binding affinity to other NADPH oxidase subunits, facilitating the assembly of the active enzyme complex and promoting ROS generation. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin, a thioredoxin reductase inhibitor, indirectly activates p47-phox by disrupting redox balance. Inhibition of thioredoxin reductase enhances oxidative stress, promoting p47-phox activation and facilitating its involvement in NADPH oxidase-mediated signaling pathways. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, directly enhances p47-phox activity by preventing inhibitory phosphorylation. Inhibition of tyrosine kinases ensures sustained p47-phox activation, leading to increased participation in NADPH oxidase-mediated signaling cascades. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I, a PKC inhibitor, indirectly activates p47-phox by preventing inhibitory phosphorylation. Inhibition of PKC relieves the negative regulation on p47-phox, ensuring sustained activation and increased involvement in NADPH oxidase-mediated signaling events. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Angiotensin II directly enhances p47-phox activity by binding to its receptor and initiating downstream signaling cascades. This activation leads to increased expression and translocation of p47-phox, promoting its participation in NADPH oxidase-mediated ROS generation. | ||||||
Thioridazine | 50-52-2 | sc-473180 | 50 mg | $500.00 | ||
Thioridazine, a calmodulin inhibitor, indirectly enhances p47-phox activity by disrupting calcium signaling. Inhibition of calmodulin prevents its inhibitory effect on p47-phox, ensuring sustained activation and increased involvement in NADPH oxidase-mediated signaling pathways. | ||||||
Pyocyanin | 85-66-5 | sc-205475 sc-205475A sc-205475B sc-205475C | 5 mg 10 mg 50 mg 100 mg | $122.00 $306.00 $1020.00 $1836.00 | 1 | |
Pyocyanin, a redox-active phenazine derivative, directly enhances p47-phox activity by promoting ROS production. The redox cycling of pyocyanin generates reactive oxygen species, activating p47-phox and facilitating its increased participation in NADPH oxidase-mediated signaling events. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a sirtuin activator, indirectly enhances p47-phox activity by modulating redox-sensitive pathways. Activation of sirtuins influences redox balance, promoting sustained p47-phox activation and increased participation in NADPH oxidase-mediated signaling cascades. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $227.00 | 8 | |
Go6976, a PKC inhibitor, indirectly activates p47-phox by preventing inhibitory phosphorylation. Inhibition of PKC relieves the negative regulation on p47-phox, ensuring sustained activation and increased involvement in NADPH oxidase-mediated signaling events. | ||||||