P2X3 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NF 449 | 389142-38-5 | sc-203159 | 10 mg | $308.00 | 5 | |
NF 449 acts as a selective antagonist of the P2X3 receptor, exhibiting a unique ability to inhibit ATP-mediated signaling. Its molecular interactions involve specific binding sites that stabilize inactive receptor conformations, effectively reducing ion channel permeability. This modulation alters downstream signaling pathways, impacting nociceptive transmission. The compound's kinetic profile reveals a rapid onset of action, allowing for detailed studies of purinergic receptor dynamics and their physiological implications. | ||||||
NF 110 | 111150-22-2 | sc-203642 sc-203642A | 10 mg 50 mg | $179.00 $754.00 | ||
NF 110 functions as a selective modulator of the P2X3 receptor, characterized by its ability to disrupt ATP binding through unique allosteric interactions. This compound alters receptor conformation, leading to a decrease in ion flow and subsequent changes in cellular excitability. Its distinct reaction kinetics allow for precise exploration of receptor activation and desensitization processes, providing insights into purinergic signaling mechanisms and their broader biological effects. | ||||||
A 740003 | 861393-28-4 | sc-291774 sc-291774A | 10 mg 50 mg | $173.00 $719.00 | 8 | |
Highly selective P2RX3 antagonist, inhibits ATP-mediated calcium influx and currents in vitro. | ||||||
A-317491 sodium salt | 475205-49-3 (free acid) | sc-300144 | 5 mg | $200.00 | ||
A-317491 sodium salt acts as a selective antagonist of the P2X3 receptor, exhibiting unique binding dynamics that stabilize the inactive receptor state. This compound influences the receptor's ion channel properties, effectively modulating calcium influx and altering downstream signaling pathways. Its distinct molecular interactions facilitate a nuanced understanding of receptor desensitization and recovery, contributing to the exploration of purinergic receptor functions in various physiological contexts. | ||||||
A-317491 | 475205-49-3 | sc-474921 | 5 mg | $150.00 | ||
A-317491 is a selective P2X3 receptor antagonist that exhibits unique allosteric modulation, influencing receptor conformation and ion permeability. Its binding affinity alters the kinetics of ATP-induced channel activation, leading to a distinct profile of receptor desensitization. The compound's interactions with specific amino acid residues provide insights into the mechanistic pathways of purinergic signaling, enhancing our understanding of receptor dynamics and their physiological implications. | ||||||
RO-3 | 1026582-88-6 | sc-204242 | 10 mg | $145.00 | ||
Selective antagonist of P2RX3. Inhibits ATP-induced calcium mobilization and ion channel currents. | ||||||
PPADS tetrasodium salt, anhydrous | 192575-19-2 | sc-202770 sc-202770A | 10 mg 50 mg | $97.00 $390.00 | 9 | |
A non-selective antagonist of P2X receptors, including P2RX3, blocks ATP-induced responses. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Non-selective P2 receptor antagonist, inhibits P2RX3 among other subtypes, by blocking ATP binding. | ||||||
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $133.00 | 20 | |
Blocks P2RX3 receptors as well as other P2X subtypes, inhibiting calcium influx. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $199.00 $460.00 $1479.00 | 1 | |
A potent P2RX1 antagonist with inhibitory effects on P2RX3, interferes with ATP binding. | ||||||