Molecular structure of RO-3, CAS Number: 1026582-88-6
RO-3 (CAS 1026582-88-6)
Alternate Names:
5-[[4,5-Dimethoxy-2-(methylethyl)phenyl]methyl]-2,4-pyrimidinediamine
Application:
RO-3 is a selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist
CAS Number:
1026582-88-6
Molecular Weight:
302.37
Molecular Formula:
C16H22N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively) that exhibits no activity at P2X1, P2X2, P2X4, P2X5 and P2X7 receptors (IC50 > 10 μM). Attenuates nociceptive sensitivity in animal models of pain. Orally active and brain penetrant.
RO-3 (CAS 1026582-88-6) References
Gever et al (2006) Pharmacology of P2X channels. Eur.J.Physiol. 452 513. Ford et al (2006) Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br.J.Pharmacol. 147 S132. Donnelly-Roberts et al (2008) Painful purinergic receptors. J.Pharmacol.Exp.Ther. 324 409.Inhibitor of:
P2X1, P2X3, and P2X5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RO-3, 10 mg | sc-204242 | 10 mg | $145.00 |