Molecular structure of A-317491 sodium salt, CAS Number: 475205-49-3 (free acid)
A-317491 sodium salt (CAS 475205-49-3 (free acid))
Alternate Names:
5-[[[(3-Phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-1,2,4-benzenetricarboxylic acid sodium salt
Application:
A-317491 sodium salt is a non-nucleotide P2X3 and P2X2/3 receptor antagonist
CAS Number:
475205-49-3 (free acid)
Molecular Weight:
565.57
Molecular Formula:
C33H27NO8•xNa
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors. It is known that P2X3 and P2X2/3 receptors stimulate the pronociceptive effects of ATP upon activation. Studies indicate that the P2X3 and P2X2/3 are stereoselective for the S enantiomer. These studies show that A-317491 sodium salt hydrate can also bind to 86 other receptors, enzymes, and ion channels.
A-317491 sodium salt (CAS 475205-49-3 (free acid)) References
- A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. | Jarvis, MF., et al. 2002. Proc Natl Acad Sci U S A. 99: 17179-84. PMID: 12482951
- [3H]A-317491, a novel high-affinity non-nucleotide antagonist that specifically labels human P2X2/3 and P2X3 receptors. | Jarvis, MF., et al. 2004. J Pharmacol Exp Ther. 310: 407-16. PMID: 15024037
- Antinociceptive properties of a non-nucleotide P2X3/P2X2/3 receptor antagonist. | McGaraughty, S. and Jarvis, MF. 2005. Drug News Perspect. 18: 501-7. PMID: 16391720
- Purinergic P2X receptor activation induces emetic responses in ferrets and Suncus murinus (house musk shrews). | Nagakura, Y., et al. 2007. Br J Pharmacol. 152: 464-70. PMID: 17700716
- Myocardial ischemic nociceptive signaling mediated by P2X3 receptor in rat stellate ganglion neurons. | Zhang, C., et al. 2008. Brain Res Bull. 75: 77-82. PMID: 18158099
- BPTU, an allosteric antagonist of P2Y1 receptor, blocks nerve mediated inhibitory neuromuscular responses in the gastrointestinal tract of rodents. | Mañé, N., et al. 2016. Neuropharmacology. 110: 376-385. PMID: 27496690
- Abacavir Induces Arterial Thrombosis in a Murine Model. | Collado-Diaz, V., et al. 2018. J Infect Dis. 218: 228-233. PMID: 29346575
- Purinergic signaling between neurons and satellite glial cells of mouse dorsal root ganglia modulates neuronal excitability in vivo. | Chen, Z., et al. 2022. Pain. 163: 1636-1647. PMID: 35027518
- Effects of Nitric Oxide on the Activity of P2X and TRPV1 Receptors in Rat Meningeal Afferents of the Trigeminal Nerve. | Koroleva, K., et al. 2023. Int J Mol Sci. 24: PMID: 37108677
- Participation of Central $ P2X_7 $ Receptors in CFA-induced Inflammatory Pain in the Orofacial Area of Rats | Yang, K. Y., Kim, M. D., Ju, J. S., Kim, M. J., & Ahn, D. K. 2014. International Journal of Oral Biology. 39(1): 49-56.
Inhibitor of:
P2X3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A-317491 sodium salt, 5 mg | sc-300144 | 5 mg | $200.00 |