p20-ARC Inhibitors
The chemical class known as p20-ARC inhibitors refers to a group of compounds designed to selectively target and inhibit the activity of p20-ARC, a protein subunit within the Arp2/3 complex. The Arp2/3 complex is a multi-protein assembly that plays a pivotal role in regulating the dynamics of the actin cytoskeleton, a crucial component of the cellular infrastructure responsible for various cellular processes, including cell motility, shape changes, and intracellular transport. p20-ARC, also known as ARPC4, is one of the seven subunits of the Arp2/3 complex, and it serves as an essential regulator of actin polymerization, contributing to the formation of branched actin filament networks. Inhibiting p20-ARC can have significant implications for understanding cellular processes driven by actin dynamics.
Researchers utilize p20-ARC inhibitors as valuable tools to investigate the precise function of the Arp2/3 complex and its role in cellular processes such as cell motility, endocytosis, and cell division. By selectively targeting p20-ARC, scientists can dissect the contributions of this subunit to actin filament assembly and dynamics, shedding light on fundamental cellular mechanisms. Additionally, the development of p20-ARC inhibitors may have applications in the study of diseases associated with dysregulated actin dynamics, including various cancers and neurodegenerative disorders. These compounds can help unravel the complex interplay of proteins involved in actin cytoskeleton regulation, providing insights into potential research strategies.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $74.00 | 256 | |
A pan-caspase inhibitor that may inhibit apoptosis regulators by blocking caspase activity. | ||||||
Q-VD-OPH | 1135695-98-5 | sc-222230 | 5 mg | $782.00 | 5 | |
A broad-spectrum caspase inhibitor that could prevent the initiation of apoptosis, potentially affecting regulators like p20-ARC. | ||||||
Emricasan | 254750-02-2 | sc-507387 | 5 mg | $90.00 | ||
A caspase inhibitor designed to reduce apoptosis, which could indirectly inhibit apoptosis regulators' expression. | ||||||
VX-765 | 273404-37-8 | sc-475845 sc-475845A sc-475845B | 5 mg 10 mg 50 mg | $224.00 $296.00 $949.00 | 1 | |
A selective caspase-1 inhibitor that might influence the expression of proteins involved in the apoptotic process. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A MEK inhibitor that can interfere with MAPK/ERK signaling, which may influence apoptotic regulatory proteins. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that could modulate apoptotic signaling pathways, possibly affecting proteins like p20-ARC. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor that may alter stress response pathways and consequently the expression of apoptosis regulators. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor with the potential to impact signaling pathways involved in apoptosis regulation. | ||||||
Stat3 Inhibitor III, WP1066 | 857064-38-1 | sc-203282 | 10 mg | $132.00 | 72 | |
An inhibitor of STAT3, which can be involved in cell survival pathways and potentially regulate apoptosis. | ||||||
SN 38 | 86639-52-3 | sc-203697 sc-203697A sc-203697B | 10 mg 50 mg 500 mg | $117.00 $335.00 $883.00 | 19 | |
The active metabolite of irinotecan, known to inhibit topoisomerase I, which can lead to apoptotic signaling. | ||||||