p15 Activators constitute a specific group of chemical compounds recognized for their capacity to modulate the activity of cyclin-dependent kinase inhibitor 2B (CDKN2B), also referred to as p15. This chemical class operates by interacting with and enhancing the signaling pathways associated with p15, a protein known for its role in cell cycle regulation and inhibition of cyclin-dependent kinases. p15 is acknowledged for its involvement in controlling cell cycle progression, cellular growth, and responses to various cellular cues.
p15 Activators exert their influence through specific molecular interactions that may amplify the downstream effects of p15-mediated signaling, contributing to the fine-tuning of cell cycle checkpoints, cellular proliferation, and differentiation. The intricate mechanisms through which p15 Activators impact p15-related pathways remain a focus of ongoing scientific exploration, offering insights into the complex interplay between cell cycle dynamics, growth control, and cellular responses to external signals. The specific ways in which this chemical class engages with p15 underscore its significance in unraveling the intricacies of cell cycle regulation and enhancing our understanding across various scientific domains.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-azacytidine demethylates DNA, allowing transcription factors to access the p15 promoter and activate its expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid induces p15 expression as cells undergo differentiation processes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
An HDAC inhibitor that affects chromatin structure, potentially leading to increased p15 expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Demethylates DNA, allowing transcription factors to access the p15 promoter and activate its expression. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin induces DNA damage and activate p53, which then induces p15 expression as part of the DNA damage response. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin induce DNA damage and activate p53, which then induces p15 expression as part of the DNA damage response. | ||||||