Date published: 2026-4-1

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OTX1 Inhibitors

OTX1 inhibitors belong to a distinctive chemical class that plays a significant role in the field of molecular biology and cellular research. These inhibitors are designed to target and modulate the activity of the OTX1 protein, which is a transcription factor belonging to the homeobox family. Transcription factors like OTX1 are pivotal in regulating gene expression and orchestrating the development and differentiation of various tissues and organs in the human body. OTX1, in particular, is involved in the development of the central nervous system and the anterior head structures during embryogenesis. Its precise regulation is crucial for proper neural patterning and craniofacial development. The chemical class of OTX1 inhibitors comprises small molecules or compounds that specifically bind to the OTX1 protein, thereby disrupting its normal function. By inhibiting OTX1, these compounds can influence the expression of downstream target genes and consequently impact developmental processes. Researchers employ OTX1 inhibitors as valuable tools in molecular biology experiments and studies aiming to decipher the intricate networks of gene regulation. Understanding the role of OTX1 and its inhibitors can shed light on the underlying molecular mechanisms involved in neural development and craniofacial morphogenesis.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

Inhibits DNA methyltransferases, which can lead to the demethylation of the Otx1 gene promoter, possibly reducing its expression.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$152.00
$479.00
$632.00
$1223.00
$2132.00
33
(3)

A histone deacetylase inhibitor that can alter chromatin structure, potentially affecting Otx1 gene expression.

Suberoylanilide Hydroxamic Acid

149647-78-9sc-220139
sc-220139A
100 mg
500 mg
$133.00
$275.00
37
(2)

Another histone deacetylase inhibitor that can influence chromatin remodeling and affect Otx1 transcription.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

An inhibitor of the MAPK/ERK pathway, which may influence Otx1 activity indirectly by modulating signaling pathways.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

A PI3K inhibitor, which can impact various signaling cascades and potentially affect Otx1-related pathways.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

Inhibits the JNK signaling pathway, which might interact with cellular processes involving Otx1.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$64.00
$246.00
136
(2)

Another MAPK/ERK pathway inhibitor that can indirectly affect Otx1 activity by altering upstream signaling.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

A p38 MAPK inhibitor, potentially impacting signaling pathways that could regulate Otx1 functions.

2-Methoxyestradiol

362-07-2sc-201371
sc-201371A
10 mg
50 mg
$71.00
$288.00
6
(1)

Can inhibit HIF-1α, which may have a downstream effect on Otx1 in hypoxic conditions.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

An mTOR inhibitor that can influence protein synthesis and cellular growth pathways, possibly affecting Otx1 function.