OTUD4 Activators
OTUD4, a deubiquitinating enzyme, can have its functional activity enhanced by chemicals that increase the cellular concentration of ubiquitinated proteins. Proteasome inhibitors like MG-132, Bortezomib, and Lactacystin prevent the degradation of ubiquitinated proteins, thereby providing more substrates for OTUD4's enzymatic activity. Ubistatins, which inhibit the binding of ubiquitinated proteins to the proteasome, and Pyr-41, an inhibitor of ubiquitin-activating enzyme E1, also lead to an accumulation of ubiquitinated proteins, thus enhancing OTUD4's deubiquitination function. PR-619, a broad-spectrum DUB inhibitor, indirectly enhances the activity of OTUD4 by increasing the levels of ubiquitinated proteins.
OTUD4's deubiquitinating activity can be further enhanced by chemicals that influence the intracellular localization and stability of ubiquitinated proteins. NMS-873, an allosteric inhibitor of p97/VCP, leads to an accumulation of ubiquitinated proteins by preventing their extraction from complexes. Similarly, Chloroquine, an inhibitor of lysosomal degradation, and Bafilomycin A1, an inhibitor of V-ATPase, prevent the degradation of ubiquitinated proteins, enhancing OTUD4's function. Leptomycin B, an inhibitor of nuclear export, could potentially enhance OTUD4's activity by affecting the localization of ubiquitinated proteins. Lastly, MLN4924, a NEDD8-activating enzyme inhibitor, leads to an accumulation of neddylated proteins. Since OTUD4 can also deubiquitinate neddylated proteins, the increased concentration of these proteins can further enhance the enzymatic activity of OTUD4. In addition, IU1, a specific inhibitor of the deubiquitinating enzyme USP14, promotes the accumulation of ubiquitinated proteins, thereby potentially boosting the deubiquitination activity of OTUD4.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that prevents the degradation of ubiquitinated proteins. OTUD4, a deubiquitinating enzyme, can be more effective due to the accumulation of ubiquitinated substrates. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $77.00 $188.00 $431.00 | 1 | |
PR-619 is a broad-spectrum DUB inhibitor, it inhibits various deubiquitinating enzymes, leading to an increase in ubiquitinated proteins. The accumulation of these proteins can enhance the activity of OTUD4. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
MLN4924 is a NEDD8-activating enzyme inhibitor that leads to the accumulation of neddylated proteins. Since OTUD4 can also deubiquitinate neddylated proteins, its activity can be enhanced. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a proteasome inhibitor. By blocking the degradation of ubiquitinated proteins, it allows for the accumulation of these proteins, enhancing the deubiquitinating activity of OTUD4. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
Pyr-41 is an inhibitor of ubiquitin-activating enzyme E1. It increases the levels of ubiquitinated proteins, which can enhance the activity of OTUD4. | ||||||
NMS-873 | 1418013-75-8 | sc-478803 | 5 mg | $300.00 | ||
NMS-873 is an allosteric inhibitor of p97/VCP, a segregase involved in the extraction of ubiquitinated proteins from complexes. The inhibition can lead to an accumulation of ubiquitinated proteins, enhancing OTUD4's deubiquitinating activity. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine inhibits lysosomal degradation, resulting in an accumulation of ubiquitinated proteins in the cytoplasm. This could enhance the deubiquitinating activity of OTUD4. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a proteasome inhibitor. It prevents the degradation of ubiquitinated proteins, thereby enhancing the activity of OTUD4. | ||||||
IU1 | 314245-33-5 | sc-361215 sc-361215A sc-361215B | 10 mg 50 mg 100 mg | $138.00 $607.00 $866.00 | 2 | |
IU1 is a specific inhibitor of the deubiquitinating enzyme USP14, leading to an accumulation of ubiquitinated proteins. This can enhance the deubiquitination activity of OTUD4. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
Leptomycin B inhibits the nuclear export of proteins, which can impact the localization of ubiquitinated proteins and potentially enhance the activity of OTUD4. | ||||||