OTTMUSG00000019265 Inhibitors
The inhibition of the protein Gm15142 involves a diverse array of chemical compounds, each targeting specific pathways and mechanisms that contribute to the protein's functional activity. Staurosporine, for instance, plays a pivotal role by inhibiting the kinase activity of Gm15142. This protein, being a kinase, is integral in phosphorylation processes within the cell. Staurosporine achieves its inhibitory effect by binding to the ATP-binding site of Gm15142, thus obstructing the transfer of a phosphate group from ATP to the protein's substrate. This action effectively hampers the kinase activity of Gm15142, leading to its functional inhibition. Similarly, LY294002 and Wortmannin target the PI3K/Akt pathway, which is crucial for the functionality of Gm15142. Both these inhibitors prevent the activation of Akt, a key player in the pathway, thereby indirectly inhibiting the downstream effects that would otherwise activate Gm15142. This illustrates how the disruption of signaling pathways upstream can lead to the functional inhibition of Gm15142.
Further exploring the landscape of Gm15142 inhibition, other chemicals like U0126 and PD98059 focus on inhibiting the MEK/ERK pathway, which is upstream of Gm15142. These inhibitors prevent the activation of MEK, subsequently leading to the reduction of Gm15142's kinase activity, as it relies on ERK signaling for full functionality. Triciribine also plays a similar role by specifically targeting Akt, further emphasizing the significance of the PI3K/Akt pathway in the regulation of Gm15142 activity. In a different approach, SP600125 and SB203580 inhibit the JNK and p38 MAPK pathways, respectively. Gm15142 is involved in both these pathways, and its activity is influenced by their signaling. By inhibiting these pathways, both SP600125 and SB203580 indirectly reduce the activity of Gm15142, showcasing how various signaling pathways converge on this protein. Furthermore, PP2 and Dasatinib inhibit Src family kinases and multiple other kinases, respectively, which are upstream regulators of Gm15142. The inhibition of these kinases results in the functional inhibition of Gm15142, emphasizing the protein's dependence on multiple upstream signaling molecules for its activity. Lastly, PD173074 targets the FGFR pathway, to which Gm15142 is functionally linked. The inhibition of FGFR by PD173074 decreases the activity of Gm15142, highlighting the intricate network of signaling pathways that regulate the protein's function. This collection of chemical inhibitors demonstrates the complex interplay of signaling pathways and molecular interactions that govern the activity of Gm15142, and how targeted inhibition at various points in these pathways can lead to the effective downregulation of this protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine inhibits Gm15142 by targeting its kinase activity. Gm15142, being a kinase, plays a critical role in phosphorylation processes. Staurosporine, a potent kinase inhibitor, binds to the ATP-binding site of Gm15142, thus preventing the transfer of a phosphate group from ATP to its substrate, leading to the functional inhibition of Gm15142’s kinase activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which is essential for the activity of Gm15142. As Gm15142 is involved in the mTOR signaling pathway, the inhibition of mTOR by Rapamycin leads to a decrease in Gm15142 activity. This is because Gm15142 requires mTOR signaling for its functional role, and blocking this pathway inhibits Gm15142 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits Gm15142 by blocking the PI3K/Akt pathway. Gm15142 is part of this signaling cascade, and its activity is dependent on the PI3K/Akt pathway. LY294002, a PI3K inhibitor, prevents the activation of Akt, subsequently inhibiting the downstream effects on Gm15142, leading to its functional inhibition. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 specifically inhibits MEK1/2, which are upstream regulators of Gm15142. By inhibiting MEK1/2, U0126 prevents the activation of the ERK pathway, a crucial pathway for Gm15142 activity. The inhibition of this pathway results in the reduction of Gm15142’s kinase activity, as it relies on ERK signaling for full functionality. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 inhibits Gm15142 by blocking MEK activation, which is upstream of Gm15142. This chemical specifically inhibits the MEK/ERK pathway, which is essential for the functional activity of Gm15142. By preventing the phosphorylation and activation of MEK, PD98059 indirectly inhibits the activity of Gm15142. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits Gm15142 by targeting the PI3K/Akt pathway. As a PI3K inhibitor, Wortmannin prevents the activation of Akt, which is necessary for Gm15142’s function. The inhibition of PI3K and subsequent inactivation of Akt leads to the functional inhibition of Gm15142, as it is reliant on the PI3K/Akt signaling for its activity. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine specifically inhibits Akt, which is part of the signaling pathway involving Gm15142. By inhibiting Akt, Triciribine indirectly inhibits Gm15142, as the protein’s activity is dependent on Akt signaling. The prevention of Akt activation leads to a decrease in Gm15142 activity, as it relies on Akt for its functional role. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 inhibits Gm15142 by targeting the JNK pathway. Gm15142 is involved in the JNK signaling pathway, and its activity is dependent on JNK signaling. By inhibiting JNK, SP600125 indirectly reduces the activity of Gm15142, as the protein requires JNK pathway activation for its functional role. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits Gm15142 through the p38 MAPK pathway. Gm15142 is involved in this pathway, and its activity is influenced by p38 MAPK signaling. By inhibiting p38 MAPK, SB203580 indirectly leads to the functional inhibition of Gm15142, as it is dependent on p38 MAPK for its activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 inhibits Gm15142 by targeting Src family kinases, which are upstream regulators of Gm15142. The inhibition of Src kinases leads to a decrease in Gm15142 activity, as Gm15142 requires Src signaling for its functional role. The blockade of Src family kinases by PP2 results in the functional inhibition of Gm15142. | ||||||