OTTMUSG00000016887 Inhibitors
Histone cluster 2 family member plays a critical role in chromatin structure and gene regulation. The chemical inhibitors listed above are primarily histone deacetylase inhibitors, hypothesized to target this protein by altering its acetylation state, which in turn influences chromatin architecture and function. Trichostatin A, Sodium Butyrate, Vorinostat, Panobinostat, and Valproic Acid, by inhibiting histone deacetylases, lead to an increased acetylation of histones, including histone cluster 2 family member. This heightened acetylation could disrupt the normal compact structure of chromatin, essential for regulated gene expression and chromatin dynamics, thus potentially impairing the function of histone cluster 2 family member.
Moreover, inhibitors like Romidepsin, Belinostat, Entinostat, Tacedinaline, Quisinostat, Mocetinostat, and Givinostat function similarly, maintaining higher levels of acetylation on histone proteins. This alteration in the chromatin structure can affect the functionality of histone cluster 2 family member in chromatin remodeling and gene regulation. The consistent theme across these inhibitors is their ability to disrupt the normal structure and function of chromatin, which is crucial for the role of histone cluster 2 family member. These potential inhibitors serve as starting points for further investigation into the modulation of histone cluster 2 family member's activity in a cellular context. It's important to emphasize that these inhibitors are not directly proven to inhibit histone cluster 2 family member but are selected based on their known action on pathways that could logically influence its activity or function.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. By increasing acetylation of histones, it can disrupt the normal function of histone cluster 2 family member in chromatin compaction and gene regulation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate, another histone deacetylase inhibitor, elevates acetylation levels of histones, potentially affecting the function of histone cluster 2 family member in chromatin organization. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid inhibits histone deacetylases, leading to increased acetylation of histones including histone cluster 2 family member, potentially disrupting its role in chromatin structure. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat, as a broad-spectrum histone deacetylase inhibitor, could indirectly impact the functionality of histone cluster 2 family member by altering chromatin acetylation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid acts as a histone deacetylase inhibitor, possibly affecting the role of histone cluster 2 family member in chromatin remodeling and gene expression control. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin, by inhibiting histone deacetylase, could increase acetylation levels of histone proteins, affecting the function of histone cluster 2 family member. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $153.00 $561.00 | ||
Belinostat inhibits histone deacetylases, potentially impacting the chromatin structure and role of histone cluster 2 family member in gene regulation. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275 increases acetylation of histone proteins, which could affect the functionality of histone cluster 2 family member in chromatin organization. | ||||||
CI 994 | 112522-64-2 | sc-205245 sc-205245A | 10 mg 50 mg | $97.00 $525.00 | 1 | |
CI 994, as a histone deacetylase inhibitor, could alter chromatin structure, impacting the role of histone cluster 2 family member. | ||||||
JNJ-26481585 | 875320-29-9 | sc-364515 sc-364515A | 5 mg 50 mg | $321.00 $1224.00 | ||
JNJ-26481585 enhances acetylation of histone proteins, potentially inhibiting the functional role of histone cluster 2 family member in chromatin organization. | ||||||