OTTMUSG00000016783 Activators
Histone cluster 2 family member (H2al1c) is a vital protein involved in chromatin remodeling and epigenetic regulation, contributing to the modulation of gene expression. Its activation is closely associated with specific chemical compounds that can modulate its function, thereby influencing gene transcription. The primary mechanism of H2al1c activation centers around the modulation of chromatin structure through histone acetylation. Compounds like Trichostatin A, Sodium Butyrate, and Valproic Acid act as histone deacetylase (HDAC) inhibitors, resulting in increased histone acetylation levels. This modification leads to a more accessible chromatin structure, facilitating the binding of transcription factors and promoting the transcriptional activation of H2al1c. Additionally, indirect activation of H2al1c can be achieved through chemicals such as Curcumin and Resveratrol, which modulate specific signaling pathways. Curcumin, for instance, activates H2al1c through the NF-κB pathway, promoting the transcription of NF-κB-responsive genes, including H2al1c. Similarly, Resveratrol influences the SIRT1 pathway by inhibiting SIRT1 deacetylase activity, resulting in increased histone acetylation and subsequent gene transcription.
Epigenetic regulation of H2al1c is facilitated by DNA methylation inhibitors like Epigallocatechin Gallate and 5-Aza-2'-deoxycytidine, which demethylate DNA at the gene promoter region, creating an active chromatin state conducive to gene transcription and protein expression. Furthermore, indirect activation through signaling pathways is observed with chemicals like SB203580 and PD98059, which affect the p38 MAPK and MEK/ERK pathways, respectively. Suppression of these pathways leads to altered gene expression patterns, including increased transcription of H2al1c via downstream signaling events. In conclusion, H2al1c's activation involves a complex interplay of histone modifications, DNA methylation, and specific signaling pathways. Understanding these mechanisms is crucial for unraveling the regulatory network of H2al1c in the context of epigenetic regulation and gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a potent inhibitor of histone deacetylases (HDACs), leading to histone hyperacetylation. This modification enhances chromatin accessibility and promotes the transcriptional activation of the H2al1c gene by allowing greater access to the gene promoter regions. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate acts as a histone deacetylase (HDAC) inhibitor, similar to Trichostatin A. It enhances histone acetylation, promoting a more permissive chromatin structure that favors gene activation of H2al1c by facilitating transcription factor binding. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid functions as an HDAC inhibitor, increasing histone acetylation levels. This modification positively influences the chromatin structure at the H2al1c gene locus, leading to enhanced gene expression through an open chromatin configuration. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been reported to activate H2al1c indirectly through the NF-κB pathway. It promotes the transcription of NF-κB-responsive genes, including H2al1c, which is positively influenced by NF-κB binding to its promoter region. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates H2al1c by modulating the SIRT1 pathway. SIRT1 deacetylase activity is inhibited by resveratrol, resulting in increased histone acetylation and, consequently, the promotion of H2al1c gene transcription. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG) functions as an activator by inhibiting DNA methyltransferases (DNMTs). By reducing DNA methylation at the promoter region of H2al1c, EGCG facilitates increased gene transcription and protein expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2'-deoxycytidine, a demethylating agent, can activate H2al1c by inhibiting DNA methyltransferases (DNMTs). It leads to DNA demethylation at the gene promoter, promoting a more active state that favors gene transcription and protein expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 activates H2al1c indirectly through the p38 MAPK pathway. Activation of p38 MAPK results in downstream signaling events that lead to transcriptional activation of target genes, including H2al1c. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 activates H2al1c indirectly by inhibiting the MEK/ERK pathway. Inhibition of this pathway leads to altered gene expression patterns, including increased transcription of H2al1c. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Sodium arsenite activates H2al1c through oxidative stress. It induces the generation of reactive oxygen species (ROS), which can activate redox-sensitive transcription factors, ultimately resulting in the upregulation of H2al1c. | ||||||