OTTMUSG00000011285 Inhibitors
Interferon zeta-like precursor, a protein encoded by the Gm13287 gene, plays a pivotal role in innate immune responses, particularly in the context of antiviral defense and immune regulation. The inhibition of this protein can be achieved through a variety of chemical inhibitors, each targeting distinct cellular pathways and mechanisms. One such inhibitor, Pifithrin-α, functions as a specific antagonist of p53, a critical regulator of cellular responses to DNA damage. By inhibiting p53, Pifithrin-α indirectly suppresses the transcriptional activation of interferon zeta-like precursor, leading to a functional inhibition of its activity. This inhibition is particularly relevant in scenarios involving DNA damage, where the protein's activity is vital in coordinating immune responses.
Another effective inhibitor, Ruxolitinib, targets the JAK1/JAK2 kinases, which are integral components of the JAK-STAT signaling pathway implicated in interferon regulation. Through the inhibition of JAK1/2, Ruxolitinib disrupts the phosphorylation and activation of STAT proteins, consequently hindering the downstream signaling events associated with interferon zeta-like precursor's functional activation. This inhibition is crucial in preventing excessive interferon responses and maintaining immune homeostasis. These examples highlight the intricate web of cellular pathways and signaling molecules involved in the regulation of interferon zeta-like precursor, demonstrating that its functional inhibition can be achieved through the precise targeting of these pathways, ensuring a fine-tuned modulation of immune responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pifithrin-α hydrobromide | 63208-82-2 | sc-45050 sc-45050A | 5 mg 25 mg | $118.00 $287.00 | 36 | |
Pifithrin-α(HBr) is a specific inhibitor of p53, a protein involved in the interferon signaling pathway. By inhibiting p53, it indirectly suppresses the transcriptional activation of interferon zeta-like precursor, thereby functionally inhibiting its activity in response to DNA damage. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $246.00 $490.00 $536.00 | 16 | |
Ruxolitinib is a JAK1/JAK2 inhibitor, which are critical kinases in the JAK-STAT pathway that mediates interferon signaling. By targeting JAK1/2, it disrupts the phosphorylation and activation of STAT proteins, leading to the inhibition of interferon zeta-like precursor's downstream signaling and functional activity. | ||||||
Fludarabine | 21679-14-1 | sc-204755 sc-204755A | 5 mg 25 mg | $57.00 $200.00 | 15 | |
Fludarabine is a nucleoside analogue that inhibits DNA synthesis. It can indirectly inhibit interferon zeta-like precursor by disrupting cell division and DNA replication, which are essential processes for interferon production and function in immune responses. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has anti-inflammatory properties and can inhibit NF-κB signaling, a pathway involved in interferon regulation. By blocking NF-κB activation, it indirectly inhibits interferon zeta-like precursor's expression and activity, particularly in inflammatory contexts. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42 is a selective inhibitor of JAK2, a kinase in the JAK-STAT pathway. By targeting JAK2, it disrupts interferon-induced STAT activation, leading to the functional inhibition of interferon zeta-like precursor's downstream effects. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a phosphoinositide 3-kinase (PI3K) inhibitor, and PI3K/AKT signaling is linked to interferon responses. Inhibiting PI3K with Wortmannin can indirectly suppress interferon zeta-like precursor's activity by interfering with downstream signaling cascades. | ||||||
Tyrphostin AG 879 | 148741-30-4 | sc-3557 sc-3557A | 5 mg 25 mg | $83.00 $328.00 | 4 | |
AG-879 is a tyrosine kinase inhibitor that can block the activity of multiple kinases involved in signaling pathways related to interferon regulation. By inhibiting these kinases, it indirectly hampers interferon zeta-like precursor's functional activation in response to various stimuli. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that can disrupt mTOR signaling pathways linked to interferon production. By inhibiting mTOR, it indirectly suppresses the translation and production of interferon zeta-like precursor, thereby functionally inhibiting its role in immune responses. | ||||||
Cidofovir | 113852-37-2 | sc-482141 | 50 mg | $135.00 | ||
Cidofovir is an antiviral agent that inhibits viral DNA polymerases. It can indirectly inhibit interferon zeta-like precursor by preventing viral replication, a process that triggers interferon responses. Cidofovir's action indirectly reduces the functional activity of the protein in antiviral defense. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective MEK inhibitor, and the MAPK/ERK pathway is involved in interferon signaling. By inhibiting MEK, it indirectly interferes with the phosphorylation events that activate interferon zeta-like precursor, resulting in its functional inhibition within the pathway. | ||||||