OTTMUSG00000010694 Inhibitors
Chemical inhibitors of OTTMUSG00000010694 function by disrupting various points along the PI3K/Akt/mTOR signaling pathway, which is integral to the regulation of protein synthesis. Rapamycin directly targets mTOR, the protein's central regulating kinase, leading to reduced activity of the protein synthesis machinery. Similarly, Torin 1, KU-0063794, PP242, AZD8055, WYE-125132, and Everolimus are selective mTOR inhibitors. These chemicals inhibit both mTORC1 and mTORC2 complexes, which are crucial for mRNA translation and protein synthesis. The inhibition of these complexes results in a decrease in the synthesis of proteins, including OTTMUSG00000010694. Palomid 529 specifically targets the mTORC1/P70S6 kinase pathway, which plays a key role in the translation of proteins, further leading to a decrease in the production of OTTMUSG00000010694.
Wortmannin and LY294002 are inhibitors of PI3K, an upstream regulator of mTOR, and by inhibiting this kinase, they cause a reduction in mTOR signaling. This results in a decrease in the activity of downstream protein synthesis. Triciribine works by preventing the activation of Akt, a kinase that is downstream of PI3K and upstream of mTOR. The inhibition of Akt by Triciribine leads to downregulated mTOR activity and thus, reduces the synthesis of OTTMUSG00000010694. Sapanisertib, by inhibiting both mTORC1 and mTORC2, also decreases the activity of these complexes and leads to the functional inhibition of proteins such as OTTMUSG00000010694. Collectively, these chemical inhibitors act on different parts of the PI3K/Akt/mTOR pathway, effectuating a comprehensive decrease in the synthesis of the protein OTTMUSG00000010694 by hindering the signaling processes that would otherwise promote its production.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR (mammalian target of rapamycin), which is a central protein in regulating cell growth and metabolism. Inhibiting mTOR could lead to a decrease in the protein synthesis of many proteins, including OTTMUSG00000010694, as mTOR is directly involved in the cap-dependent translation initiation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor. PI3K is upstream of the Akt/mTOR pathway, which is involved in protein synthesis. By inhibiting PI3K, Wortmannin would lead to reduced activity of mTOR, thus functionally inhibiting the synthesis of proteins including OTTMUSG00000010694. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor, functioning similarly to Wortmannin. By inhibiting PI3K and thereby disrupting the PI3K/Akt/mTOR signaling pathway, LY294002 would inhibit the activity of mTOR and subsequently decrease the synthesis of proteins such as OTTMUSG00000010694. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine specifically inhibits the activation of Akt, a kinase downstream of PI3K and upstream of mTOR. By preventing Akt phosphorylation and activation, Triciribine would downregulate mTOR activity, leading to a functional inhibition of proteins including OTTMUSG00000010694. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
Torin 1 is a selective mTOR inhibitor that can block both mTORC1 and mTORC2 complexes. Inhibition of these complexes would lead to a direct decrease in the protein synthesis machinery, functionally inhibiting the synthesis of various proteins, including OTTMUSG00000010694. | ||||||
KU 0063794 | 938440-64-3 | sc-361219 | 10 mg | $209.00 | ||
KU-0063794 is a selective inhibitor of mTOR that can block both mTORC1 and mTORC2, similar to Torin 1. This inhibition would suppress the protein synthesis machinery, impacting the synthesis of proteins including OTTMUSG00000010694. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
PP242 is an mTOR inhibitor that functions to inhibit both mTORC1 and mTORC2 complexes. By inhibiting mTOR signaling, PP242 would functionally inhibit the synthesis of proteins such as OTTMUSG00000010694. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $160.00 $345.00 | 12 | |
AZD8055 is a potent and selective inhibitor of mTOR kinase, inhibiting both mTORC1 and mTORC2 complexes. This would inhibit the protein synthesis pathways, functionally inhibiting the synthesis of proteins including OTTMUSG00000010694. | ||||||
Palomid 529 | 914913-88-5 | sc-364563 sc-364563A | 10 mg 50 mg | $300.00 $1000.00 | ||
Palomid 529 (P529) inhibits the mTORC1/P70S6 kinase pathway, which is essential for the translation of proteins. By inhibiting this pathway, P529 would decrease the synthesis of proteins including OTTMUSG00000010694. | ||||||
WYE-125132 | 1144068-46-1 | sc-364651 sc-364651A | 10 mg 50 mg | $510.00 $1536.00 | ||
WYE-132 is a highly potent inhibitor of mTOR, which can inhibit both mTORC1 and mTORC2 complexes. This inhibition leads to a decrease in protein synthesis, thereby functionally inhibiting the synthesis of proteins such as OTTMUSG00000010694. | ||||||