Palomid 529 (CAS 914913-88-5)
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Palomid 529 is a novel inhibitor of PI3K, Akt, and mTOR. Palomid 529 is an inhibitor of the TORC1 and TORC2 complexes and inhibits Akt signaling and mTOR signaling in similar ways in vasculature and tumor. Palomid 529 is an inhibitor of tumor growth, angiogenesis, and vascular permeability. Palomid 529 has the additional benefit of blocking pAktS473 signaling consistent with blocking TORC2 in all cells and thus bypassing feedback loops that lead to increased Akt signaling in some tumor cells. Palomid 529 inhibited both VEGF-driven (IC50 = 20 nM) and bFGF-driven (IC50 = 30 nM) endothelial cell proliferation and retained the ability to induce endothelial cell apoptosis. Palomid 529 significantly enhanced the antiproliferative effect of radiation in prostate cancer cells.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Palomid 529, 10 mg | sc-364563 | 10 mg | $300.00 | |||
Palomid 529, 50 mg | sc-364563A | 50 mg | $1000.00 |