Molecular structure of WYE-125132, CAS Number: 1144068-46-1
WYE-125132 (CAS 1144068-46-1)
Application:
WYE-125132 is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor
CAS Number:
1144068-46-1
Purity:
≥98%
Molecular Weight:
519.6
Molecular Formula:
C27H33N7O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
WYE-125132 is a potent, ATP-competitive inhibitor of recombinant mTOR kinase,with an IC50 of 0.19 nM. WYE-125132 shows an anti-proliferative activity against a variety of tumor cell lines with IC50 ranging from 2 nM (LNCap) to 380 nM (HTC116), in vitro. WYE-125132 causes inhibition of protein synthesis and cell size, induction of apoptosis, and cell cycle progression. WYE-125132 causes pre-tRNA Leu synthesis reduction by 72%, 80%, and 53% in actively proliferating cells of MG63, MDA361, and HEK293, respectively as a result of the inhibition of mTORC1. WYE-125132 induces Maf1 dephosphorylation and its accumulation in the nucleus.
Inhibitor of:
4E-BP1, C1orf14_1700012A16Rik, D1Ertd622e, dystrotelin, FOXO1, hamartin, LAMTOR4, MGRN1, MIOS, mTOR, OTTMUSG00000010694, REDD-2, SZT2, Tor1, Tor2, and TORC1.Activator of:
SRP68.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WYE-125132, 10 mg | sc-364651 | 10 mg | $510.00 | |||
WYE-125132, 50 mg | sc-364651A | 50 mg | $1536.00 |