OTTMUSG00000002045 Activators

Transmembrane protein 92-like (TM92L), a protein encoded by the Gm11546 gene, plays a pivotal role in cellular signaling and orchestrating various intracellular processes. TM92L's activation is crucial for the precise regulation of cellular responses and its involvement in multiple signaling pathways. TM92L activation involves a sophisticated interplay of chemical activators that functionally activate the protein. These activators directly engage with TM92L or indirectly influence pathways associated with it. For instance, Forskolin activates TM92L by stimulating adenylate cyclase, resulting in elevated levels of cyclic AMP (cAMP). Increased cAMP levels trigger downstream signaling events that activate TM92L. Retinoic acid, another activator, binds to TM92L's retinoic acid receptor, facilitating transcriptional activation. Epinephrine activates TM92L through the β-adrenergic receptor, initiating a G-protein cascade that ultimately leads to TM92L activation. Calcitriol enhances TM92L's transcriptional activity by binding to its receptor, while dopamine activates TM92L via dopamine receptors, triggering intracellular signaling pathways.

Insulin activates TM92L by binding to its receptor, leading to phosphorylation and activation. Cyclic AMP directly engages with TM92L, initiating downstream signaling events. Prostaglandin E2 (PGE2) activates TM92L through G-protein-coupled receptors, initiating intracellular signaling cascades. Thyroid Hormone (T3) activates TM92L by binding to thyroid hormone receptors, resulting in transcriptional responses. Glutamate activates TM92L by binding to glutamate receptors and initiating downstream signaling pathways. Additionally, Phorbol 12-myristate 13-acetate (PMA) activates TM92L by activating protein kinase C (PKC), promoting phosphorylation and subsequent activation. Sodium Orthovanadate activates TM92L by inhibiting protein tyrosine phosphatases, leading to increased phosphorylation and activation. In conclusion, TM92L is a crucial player in cellular signaling, and its functional activation is achieved through a variety of chemical activators, each with specific mechanisms ensuring precise control of cellular processes. These activators directly engage with TM92L or indirectly influence pathways associated with the protein, enabling cells to respond effectively to various external cues.