Ott Activators
Ott, a protein of significant importance in cellular biology, plays a pivotal role in the orchestration of various cellular processes. This multifaceted protein is involved in processes such as negative regulation of apoptosis, negative regulation of transcription, DNA-templated, and positive regulation of cell population proliferation. With its activity predicted to encompass ubiquitin ligase-substrate adaptor functions, Ott acts as a key player in the cell's regulatory network. Its versatile nature allows it to partake in multiple cellular pathways, ultimately impacting cellular behavior. Activation of Ott is a complex process governed by a range of signaling mechanisms. Ott's role in cellular processes hinges on its participation in specific signaling pathways, such as those associated with calcium ions, cyclic AMP (cAMP), and protein kinases. Calcium signaling, which relies on the influx of calcium ions into the cell, stimulates Ott's activity and involvement in pathways governed by calcium-dependent processes. Cyclic AMP serves as another activation trigger, with chemicals like Forskolin elevating intracellular cAMP levels, subsequently activating protein kinase A (PKA), leading to the phosphorylation and activation of Ott.
Additionally, Ott's interaction with protein kinases and phosphatases plays a significant role in its activation. For instance, PMA (Phorbol 12-myristate 13-acetate) stimulates Ott by activating protein kinase C (PKC), while Sodium Orthovanadate inhibits protein tyrosine phosphatases (PTPs), resulting in Ott's activation through increased protein phosphorylation. These complex mechanisms collectively contribute to Ott's ability to influence cellular processes and ensure its participation in diverse signaling pathways. In summary, Ott is a versatile protein involved in cellular processes such as apoptosis regulation, transcriptional control, and cell population proliferation. Its activation is intricately tied to the regulation of specific signaling pathways, including calcium signaling, cyclic AMP pathways, and various kinase-dependent processes. Ott's role in cellular regulation is crucial for maintaining proper cellular function and behavior, highlighting its significance in the intricate web of cellular biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin activates Ott by inducing calcium influx into cells. Elevated intracellular calcium levels activate calcium-dependent pathways, leading to Ott's functional activation and its involvement in regulating processes influenced by calcium signaling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Ott by stimulating protein kinase C (PKC), which phosphorylates and activates Ott. This activation enhances Ott's participation in cellular signaling pathways and its contribution to processes regulated by PKC-dependent pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin activates Ott by disrupting calcium homeostasis within cells. The resulting increase in intracellular calcium levels triggers Ott's involvement in calcium-dependent signaling pathways, influencing cellular processes influenced by calcium signaling. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium Orthovanadate activates Ott by inhibiting protein tyrosine phosphatases (PTPs). This inhibition leads to increased protein phosphorylation and Ott's participation in phosphorylation-dependent signaling pathways, impacting various cellular processes. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 activates Ott by acting as a calcium ionophore, elevating intracellular calcium levels. This activation stimulates Ott's involvement in calcium-dependent signaling pathways, influencing cellular processes modulated by calcium signaling. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
dBcAMP activates Ott by mimicking the effects of cAMP. It elevates intracellular cAMP levels, which subsequently activate Ott through PKA-mediated phosphorylation. This facilitates Ott's role in specific signaling pathways related to cellular processes. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
GF 109203X activates Ott by inhibiting protein kinase C (PKC). PKC inhibition leads to Ott's dephosphorylation and activation, facilitating its role in PKC-dependent signaling pathways and influencing various cellular processes. | ||||||
NSC 87877 | 56990-57-9 | sc-204139 | 50 mg | $137.00 | 12 | |
NSC-87877 activates Ott by modulating the activity of Src family kinases. By influencing Src kinase-dependent signaling pathways, it enhances Ott's functional activation, contributing to Ott's involvement in cellular processes regulated by these pathways. | ||||||
CA 1001 | 58801-34-6 | sc-202512 | 25 mg | $163.00 | 2 | |
Calcium Ionophore I (CI I) activates Ott by promoting calcium influx into cells. Increased intracellular calcium levels activate calcium-dependent pathways, facilitating Ott's role in specific signaling pathways related to cellular processes. | ||||||
N6-Cyclopentyladenosine | 41552-82-3 | sc-204117 | 50 mg | $120.00 | 2 | |
N6-Cyclopentyladenosine activates Ott by binding to adenosine receptors, leading to intracellular signaling changes. This activation influences Ott's participation in adenosine receptor-dependent pathways, affecting various cellular processes. | ||||||