ORP-10 Activators
ORP-10 Activators are a collection of chemical compounds that work through various biological mechanisms to enhance the functional activity of ORP-10, a protein involved in lipid signaling and transport. Forskolin indirectly enhances ORP-10's activity by increasing intracellular cAMP levels, leading to the activation of PKA which may phosphorylate components within the lipid signaling pathways where ORP-10 operates. The activator Phorbol 12-myristate 13-acetate (PMA) functions as a potent protein kinase C (PKC) activator, which can modulate lipid signaling pathways, potentially leading to the activation of ORP-10's role in lipid homeostasis. Sphingosine-1-phosphate, through its action on sphingosine-1-phosphate receptors, could activate downstream pathways like PI3K/Akt, potentially leading to the enhancement of ORP-10's activity in lipid signaling.
Furthermore, the selective PI3K inhibitor LY294002 may enhance ORP-10 by reducing competition in lipid signaling pathways, while U0126, a MEK inhibitor, could indirectly augment ORP-10 activity via shifts in signaling dynamics related to lipid metabolism. SB203580, by inhibiting p38 MAPK, and FTY720, as a sphingosine-1-phosphate receptor modulator, can each influence lipid signaling cascades that involve ORP-10. Additionally, compounds like 5-Azacytidine, which affects gene expression, and A23187, a calcium ionophore, could influence cellular signaling pathways to activate ORP-10. Lastly, WY-14643, a PPARα agonist, may enhance ORP-10 activity by upregulating genes involved in lipid metabolism, further influencing ORP-10's functional activity in lipid transport and signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a labdane diterpenoid that activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate target proteins, potentially leading to the enhancement of ORP-10 activity in lipid signaling and transport. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diester of phorbol and functions as a potent protein kinase C (PKC) activator. By activating PKC, PMA can modulate lipid signaling pathways, possibly resulting in the activation of ORP-10's role in lipid homeostasis and intracellular signaling. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate is a signaling lipid that can activate sphingosine-1-phosphate receptors, influencing downstream pathways like PI3K/Akt, which could lead to the activation of ORP-10 in lipid signaling and transport. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of PI3K. By inhibiting PI3K, it may enhance ORP-10 activity by reducing competition in lipid signaling pathways where ORP-10 is involved, possibly leading to increased lipid transport activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK. Inhibition of p38 MAPK could lead to the enhancement of ORP-10 activity by altering signaling cascades that involve lipid signaling and metabolism, where ORP-10 is a participant. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
FTY720 is a sphingosine-1-phosphate receptor modulator. Following phosphorylation, it can activate these receptors, potentially influencing signaling pathways that could lead to the activation of ORP-10 in lipid transport and signaling processes. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor which may enhance ORP-10 activity by affecting signaling pathways that involve phosphorylation events, possibly influencing ORP-10's role in lipid signaling. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a compound that incorporates into RNA and DNA, affecting methylation patterns. It could indirectly enhance ORP-10 activity by altering the expression of genes that regulate pathways involved in lipid metabolism where ORP-10 functions. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, thus potentially activating calcium-dependent signaling pathways that could lead to the activation of ORP-10 in lipid processing and signaling. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $136.00 | 7 | |
WY-14643 is a PPARα agonist that can enhance the expression of genes involved in lipid metabolism. By activating PPARα, it could indirectly lead to the enhancement of ORP-10 activity in lipid transport and signaling pathways. | ||||||