ORNT2 Activators
ORNT2 activators, such as Forskolin, IBMX, and capsaicin, enhance the functional activity of ORNT2 through various mechanisms. Forskolin and IBMX increase intracellular cAMP levels, with Forskolin directly activating adenylate cyclase responsible for cAMP production, while IBMX prevents cAMP degradation by inhibiting phosphodiesterase. The increased cAMP levels enhance Gs protein signal transduction linked with ORNT2, thereby promoting its functionality. Cholera toxin and Pertussis toxin also modulate the Gs protein pathway, with Cholera toxin prolonging Gs protein activation through ADP-ribosylation and Pertussis toxin increasing cAMP levels by decreasing adenylate cyclase inhibition. Capsaicin, another ORNT2 activator, increases intracellular calcium levels, triggering signaling events leading to ORNT2 activation.
Additional ORNT2 activators, such as Gallein, GDP-β-S, YM-254890, and Picrotoxin, along with compounds like U73122, SQ 22536, and NF449, influence ORNT2 activation through modulation of G protein signaling and other pathways. Gallein and YM-254890 modulate G protein signaling, while GDP-β-S impacts the G protein activation/deactivation cycle, and Picrotoxin increases neuronal excitability as a GABAA receptor antagonist. U73122, a phospholipase C inhibitor, SQ 22536, an adenylate cyclase inhibitor, and NF449, a potent Gs protein inhibitor, all influence the functional activity of ORNT2 via different pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylate cyclase, an enzyme responsible for producing cAMP. The increase in cAMP levels enhances the signaling of Gs proteins, which are known to be associated with ORNT2. The activation of Gs proteins can lead to increased functional activity of ORNT2. | ||||||
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $66.00 $280.00 $1300.00 | 11 | |
Picrotoxin is a GABAA receptor antagonist, and by increasing neuronal excitability, it indirectly influences olfactory signal transduction. As ORNT2 is involved in olfactory signal transduction, the increased excitability can enhance the functional activity of ORNT2. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin can increase intracellular calcium levels, which can trigger signaling events related to ORNT2 activation. The increase in calcium concentration can directly enhance functional activity of ORNT2. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonselective phosphodiesterase inhibitor. It increases cAMP levels by preventing cAMP degradation, which can enhance Gs protein signal transduction associated with ORNT2, leading to increased activity of ORNT2. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
Pertussis toxin decreases the inhibition of adenylate cyclase by ADP-ribosylating Gi/o proteins, leading to increased cAMP levels. The increase in cAMP levels enhances Gs protein signal transduction associated with ORNT2, leading to its increased functional activity. | ||||||
Gallein | 2103-64-2 | sc-202631 | 50 mg | $83.00 | 20 | |
Gallein is a Gβγ signaling inhibitor. It modulates G protein signaling which can indirectly influence the activation of ORNT2 because the functional activity of ORNT2 is related to G protein signaling. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $93.00 $356.00 | 13 | |
SQ 22536 is an adenylate cyclase inhibitor. Despite its inhibitory action, its presence can modulate adenylate cyclase activity, leading to altered cAMP levels and thus influencing the functional activity of ORNT2. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $199.00 $460.00 $1479.00 | 1 | |
NF449 is a potent Gs protein inhibitor. Despite its inhibitory action, its presence can alter Gs protein signal transduction, potentially leading to enhanced functional activity of ORNT2. | ||||||
YM 254890 | 568580-02-9 | sc-507356 | 1 mg | $500.00 | ||
YM-254890 is a selective Gq protein inhibitor. By modulating G protein signaling, it can indirectly enhance the functional activity of ORNT2. | ||||||