ORC5 Inhibitors
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin is a tetracyclic diterpene antibiotic that specifically inhibits DNA polymerase α and δ, which are required for DNA synthesis. ORC5 is a component of the origin recognition complex (ORC) essential for the initiation of DNA replication; by inhibiting DNA polymerases, aphidicolin can prevent the progression of the replication fork where ORC5 functions, thereby indirectly inhibiting ORC5's activity in replication initiation. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor that prevents the religation of single-strand DNA breaks. As topoisomerase I function is crucial for relieving torsional strain during DNA unwinding, its inhibition can indirectly hinder ORC5 activity by preventing the necessary unwinding of DNA at replication origins. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide is a chemotherapeutic agent that inhibits DNA topoisomerase II, leading to DNA strand breaks. Inhibition of topoisomerase II can result in the dysfunction of the replication fork structures, indirectly inhibiting ORC5's role in replication initiation. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $279.00 | 8 | |
Mitoxantrone is a topoisomerase II inhibitor that disrupts DNA synthesis and repair. This inhibition can indirectly affect ORC5 by stabilizing topoisomerase II cleavage complexes at replication origins where ORC5 is active, thereby blocking the progression of DNA replication where ORC5 operates. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA at the transcription initiation complex and prevents elongation by RNA polymerase. By intercalating into DNA, it can indirectly inhibit ORC5's function by physically blocking the replication complex assembly at origins of replication. | ||||||
Daunorubicin hydrochloride | 23541-50-6 | sc-200921 sc-200921A sc-200921B sc-200921C | 10 mg 50 mg 250 mg 1 g | $103.00 $429.00 $821.00 $1538.00 | 4 | |
Daunorubicin is an anthracycline antibiotic that intercalates DNA and inhibits topoisomerase II, leading to breaks in double-stranded DNA. This inhibition impacts the replication fork and can indirectly inhibit ORC5's role in the initiation and progression of replication. | ||||||
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $147.00 $258.00 $508.00 $717.00 $1432.00 | 1 | |
1-β-D-Arabinofuranosylcytosine is a nucleoside analog that inhibits DNA polymerase, halting DNA replication. This inhibition can indirectly affect ORC5 by disrupting the DNA replication process in which ORC5 is involved, inhibiting its function at the replication origins. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
Gemcitabine is a nucleotide analog that inhibits DNA synthesis. By incorporation into DNA, it leads to chain termination during DNA replication. This action can indirectly inhibit the function of ORC5 by disrupting the normal progression of replication forks where ORC5 operates. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts protein transport by inhibiting the exchange of GDP for GTP on ADP-ribosylation factors, which are GTP-binding proteins involved in vesicle formation. Disruption of protein transport can indirectly inhibit ORC5 by preventing proper localization and function of the proteins necessary for the initiation of replication, including those in the ORC complex. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation by blocking the formation of dolichol-linked oligosaccharides. Since some proteins involved in DNA replication may require glycosylation for proper function, the inhibition of glycosylation can indirectly impact ORC5's role in DNA replication initiation. | ||||||