Molecular structure of Aphidicolin, CAS Number: 38966-21-1
Aphidicolin (CAS 38966-21-1)
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Alternate Names:
Aphidicolin is also known as APC.
Application:
Aphidicolin is a novel tetracyclic diterpene antibiotic and also a DNA synthesis inhibitor in eukaryotes.
CAS Number:
38966-21-1
Purity:
≥98%
Molecular Weight:
338.48
Molecular Formula:
C20H34O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Aphidicolin is a diterpene fungal metabolite that blocks the cell cycle at early S-phase. In addition, Aphidicolin is a tetracyclic diterpene antibiotic with antiviral and antimitotic properties. Aphidicolin is a specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Aphidicolin is useful for cell synchronization. Aphidicolin prolongs the half life of DNA methyltransferase. Aphidicolin acts synergistically with vincristine and doxorubicin. Aphidicolin is also known as APC, ICI 69653, ICI-69653, ICI69653, and (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Aphidicolin (CAS 38966-21-1) References
- Cytotoxicity of aphidicolin and its derivatives against neuroblastoma cells in vitro: synergism with doxorubicin and vincristine. | Michaelis, M., et al. 2000. Anticancer Drugs. 11: 479-85. PMID: 11001389
- Subcellular localization of aphidicolin biosynthetic enzymes heterologously expressed in Aspergillus oryzae. | Ban, A., et al. 2018. Biosci Biotechnol Biochem. 82: 139-147. PMID: 29191129
- Effect of Aphidicolin, a Reversible Inhibitor of Eukaryotic Nuclear DNA Replication, on the Production of Genetically Modified Porcine Embryos by CRISPR/Cas9. | Navarro-Serna, S., et al. 2022. Int J Mol Sci. 23: PMID: 35216252
- Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells. | Groelly, FJ., et al. 2022. Mol Cell. 82: 3382-3397.e7. PMID: 36002001
- Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-alpha. | Ikegami, S., et al. 1978. Nature. 275: 458-60. PMID: 692726
- Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization. | Urbani, L., et al. 1995. Exp Cell Res. 219: 159-68. PMID: 7628532
- Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3. | Borner, MM., et al. 1995. Cancer Res. 55: 2122-8. PMID: 7743512
- TrkA neurogenic receptor regulates differentiation of neuroblastoma cells. | Poluha, W., et al. 1995. Oncogene. 10: 185-9. PMID: 7824271
- Life, death and genomic change in perturbed cell cycles. | Schimke, RT., et al. 1994. Philos Trans R Soc Lond B Biol Sci. 345: 311-7. PMID: 7846128
- A general protocol for evaluating the specific effects of DNA replication inhibitors. | Levenson, V. and Hamlin, JL. 1993. Nucleic Acids Res. 21: 3997-4004. PMID: 8371975
- Coordinate regulation of G- and C strand length during new telomere synthesis. | Fan, X. and Price, CM. 1997. Mol Biol Cell. 8: 2145-55. PMID: 9362059
- Effect of aphidicolin on DNA methyltransferase in the nucleus. | Suetake, I., et al. 1998. Cell Struct Funct. 23: 137-42. PMID: 9706402
- Aphidicolin: A Specific Inhibitor Of Nuclear Dna Replication In Eukaryotes | Silvio Spadari, et al. 1982. Trends In Biochemical Sciences. 7: 29-32.
Inhibitor of:
2410076I21Rik, 2610002J02Rik, 4632434I11Rik, 6030422M02Rik, ACTR5, ARGLU1, ATAD5, ATP5, ATP5ATP5L2, ATPAF1, BC005561, BCS1L, C15orf42, C19orf57, C1D, C20orf43, C6orf167, C8orf45, Cables1, CAF-1 p150, CARF, CAS4, CCDC57, CCDC79, Cdc14a phosphatase, Cdc45, Cdt1, CELF5, CENP-B, CMPK, CNG-3, COA5, CPA1, CPA4, CTAGE5, CTGLF5, CWF19L1, CWF19L2, CXorf39, CXorf57_D330045A20Rik, cystatin SA, Dbf4b, DBR1, DCC1, DDX16, DDX30, DDX31, DDX54, Dematin, DNA Ligase I, DNA Ligase III, DNA pol α, DNA pol β, DNA pol δ 2, DNA pol δ 3, DNA pol δ 4, DNA pol δ cat, DNA pol ε 4, DNA pol ε B, DNA pol ε ss, DNA pol γ2, DNA pol λ, DNA pol ν, DNA pol θ, DNA pol ζ, DNA pol 4, DNA pol alpha, DNA Polymerase, DNAL4, ESCO2, Etaa1, ETAA16, EXDL1, F1-ATPase, F730047E07Rik, FAM64A, Ggnbp2, Gm606, GNL2, GPSN2, H2-M10.6, H2-M5, H2AL2, Hairy, hDcp2, HEL308, HELIC1, Hfm1, Histone cluster 1 H2AF, hnRNP A0, Hop2, HSV-1 VP22, I-SceI, IGHMBP2, INO80B, INO80E, IQCF4, Isw1p, Jaz, Junctophilin-1, Khdc1c, KIAA0460, KIAA1530, KRTAP14, KRTAP16-7, KRTAP9-L3, LDH-AL6A, Lipocalin-5, LMLN, LOC100039269, LOC100039346, LOC100040585, LOC100040870, LOC100041102, LOC100041296, LOC143666, LOC345643, LOC441005, LOC643862, LOC644277, LOC645967, LOC646762, Magmas, MCM3AP, Mec3, MEIOB, MGC87042, MMR2, MND1, MRT-2, MTO1, MUP17, MUP18, MYADML2, Myosin IXb, NAP1L1, Ncapd3, NSE4A, OBFC2A, OBFC2B, OFCC1, ORC1_Orc1, OSCP, OXA1L, p91, PC-PLD4, PIF1, PLK4, PMPCA, Pol III RPC32, POLDIP2, Polyoma virus large T antigen, POP5, POTE14, PRIM1, PRIM2A, Psf1, Psf3, PTTG2, Rad24, RBM19, RBM32B, RBMY1F, RCC2, RCCD1, REPIN1, REV1, REXO1, RFC, RFC2, RFC3, RNase HII-A, RPA 34 kDa subunit, RPA135, RPA40, Rpb1, Rrn3, Rsf-1, RuvA, RWDD2A, SAS10, SCAF1, scc-112_Pds5a, Sec24D, Separase, Sgs1, SLD5, SLX1A/B_SLX1, SMC2, SMC6, SMF_Hmgxb3, SMUG1, Spartan, ss DNA marker, STAG3, SYCE1, TdTIF1 (DNTTIP1), TFIIH 2C, Tim22, Timeless, TMEM45A, TMUB1, Tns, TRIP, TSPAN18, UCRC, UIMC1, WDHD1, XRCC1, ZCCHC7, and ZNF746.Activator of:
ASF1A, ATPAF1, ATR, Baculovirus gp64, BC055324, Bir1, C15orf41, C17orf53, C20orf43, CAF-1 p150, Cdc25C, Cdc2B, CENP-S, Chk1, Chk2, Clb5, CRF-BP, CTF8, cyclin δ-3, DCC1, Dclre1c, DDX42, DinB, DNA pol δ 2, DNA pol ε A, DNA pol ζ, DNA2L, DUE-B, Eme1, EndoV, Esp1, EXOD1, F1-ATPase, FAM111A, FAM128A, FANCB, FANK1, FASP1, Gap 1, Geminin, GEN1, gp210, hCAP-G, IRAP, LIN-35, LOC641776, LOC643862, LRWD1, MBD4, MCM5, MCM6, MCM9, Microcephalin, Mitotic Cells, MLH3, MMR2, MYBBP1A, Nek8, Nop1p, NSE1, ORC2_Orc2, ORC3, ORC4, PARP-8, POL H, Pol2, POLA2, Psf2, Rad3, Rad51, Rad9, REV1, RFC5, RMI2, RNase HII-C, Rnr1, RPA 14 kDa subunit, RPA 70 kDa subunit, RPA16, SLX1A/B_SLX1, SMC1β, SPATA22, SPHAR, Srs2, TFIIH p62, TFIIH p80, TGIF2LX1, TIGD1, TREX-2, UBE2T, Wee 1, ZRANB3, and ZW10.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aphidicolin, 1 mg | sc-201535 | 1 mg | $84.00 | |||
Aphidicolin, 5 mg | sc-201535A | 5 mg | $306.00 | |||
Aphidicolin, 25 mg | sc-201535B | 25 mg | $1104.00 |