Brefeldin A CAS: 20350-15-6
MF: C16H24O4
MW: 280.36
A fungal metabolite exhibiting a wide range of antibiotic activities and activator of caspase-3.

Brefeldin A (CAS 20350-15-6)

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Sinonimo: γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone, Ascotoxin, BFA, Cyanein, Decumbin
Applicazione: A fungal metabolite exhibiting a wide range of antibiotic activities and activator of caspase-3
Numero CAS: 20350-15-6
Purezza: ≥98%
Peso molecolare: 280.36
Formula molecolare: C16H24O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
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Brefeldin A is a fungal metabolite that disrupts the structure and function of the Golgi apparatus. The compound induces the Golgi proteins to redistribute into the ER and blocks the secretion from the Golgi apparatus. Studies show that it blocks the GTP-dependent interaction of ARF with the Golgi membrane, thus inhibiting the assembly of coatomer onto the membrane. Research shows that Brefeldin A can induce apoptosis in Neuroendocrine tumor cells by activating caspase-3, and inhibits cell growth by targeting the cell cycle in prostate cancer cells. Brefeldin A is an inhibitor of ARF.


Referenze

1. Lippincott-Schwartz, J., et al. 1990. Cell. 60: 821-836. PMID: 2178778
2. Orci, L, et al. 1991. Cell. 64: 1183-1195. PMID: 2004424
3. Donaldson, J.G., et al. 1991. J. Cell Biol. 112: 579-588. PMID: 1993732
4. Donaldson, J.G., et al. 1991. Science. 254: 1197-1199. PMID: 1957170
5. Donaldson, J.G., et al. 1992. Nature. 360: 350-352. PMID: 1448151
6. Helms, J.B. and Rothman, J.E. 1992. Nature. 360: 352-354. PMID: 1448152
7. Randazzo, P.A., et al. 1993. J. Biol. Chem. 268: 9555-9563. PMID: 8486645
8. Larsson, D.E., et al. 2010. Anticancer Res. 30: 149-156. PMID: 20150630
9. Rajamahanty, S., et al. 2010. J. Biomed. Sci. 17: 5. PMID: 20102617

Stato fisico :
Solid
Derivato da :
Eupenicillum sp. UN88
Solubilità :
Soluble in water (Partly miscible), methanol (10 mg/mL), ethanol (5 mg/mL), DMSO (20 mg/mL), acetone, and ethyl acetate (1 mg/mL).
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
200° C
Punto di ebollizione :
~492.7° C at 760 mmHg (Predicted)
Densità :
~1.1 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.51
Attività ottica :
α20/D 96°±2° in methanol; α20/D 93°, c = 2 in methanol
IC50 :
B-cell specific antigen receptor-induced NF-kB activation: IC50 = 420 nM (HEK-293T cell line)
Valori pK :
pKa: 12.92
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
RTECS :
GY8410000
PubChem CID :
5287620
Indice Merck :
14: 1369
Numero MDL :
MFCD00083258
Numero EC :
247-104-4
Registro Beilstein :
25191

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Brefeldin A  Citazioni prodotti

Vedi quanti altri hanno usato Brefeldin A. Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a10 di 10 totali

PMID: # 29295953  Shim, SM. et al. 2018. Sci Signal. 11:

PMID: # 27818291  Wanka, L. et al. 2017. Cell. Signal. 29: 233-239.

PMID: # 27121042  Schumacher, MM. et al. 2016. J. Lipid Res. 57: 1286-99.

PMID: # 24943726  Vogelzang, A. et al. 2014. J. Infect. Dis. 210: 1928-37.

PMID: # 25319670  Chang, FY. et al. 2014. Biochemistry. 53: 7123-31.

PMID: # 22998223  Luo, Y. et al. 2013. Traffic. 14: 97-106.

PMID: # 22767227  Cai, Q. et al. 2012. FASEB J. 26: 3306-20.

PMID: # 22275357  Tachikawa, M. et al. 2012. The Journal of biological chemistry. 287: 8398-406.

PMID: # 16467202  Zernecke A, et al. 2006. Blood. 107(11): 4240-4243.

PMID: # 26942056  Gao, J.|Duan, Z.|Zhang, L.|Huang, X.|Long, L.|Tu, J.|Liang, H.|Zhang, Y.|Shen, T.|Lu, F.| et al. Oncoimmunology. 5: e1048061.

Ciatazioni 1 a10 di 10 totali
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