OR9A2 Inhibitors
OR9A2 inhibitors encompass a range of chemical compounds that target the olfactory receptor OR9A2, which is responsible for the detection of specific odorant molecules. 1,8-Cineole and camphor, both terpenoids, act as competitive inhibitors by binding directly to the active site of OR9A2, thus preventing the interaction with the odorant molecules that would normally initiate a signal transduction cascade. Similarly, menthol, despite its cooling sensation, alters the function of G-protein coupled receptors like OR9A2, possibly through membrane disruption or receptor conformational changes. Heavy metal salts such as zinc acetate and copper sulfate are known to stabilize olfactory receptors in an inactive conformation, thereby inhibiting their signaling capabilities.
Other inhibitors affect OR9A2 activity indirectly through the modulation of associated signaling pathways or cellular components. Capsaicin, a pungent compound in hot peppers, activates TRPV1 channels that can lead to reduced cAMP levels, which in turn may impede OR9A2 signaling. Chloroquine, an antimalarial drug, can interfere with glycosylation of membrane proteins, potentially reducing OR9A2 function. Ruthenium Red and tetraethylammonium influence intracellular calcium levels and membrane potential, respectively, which are critical for the proper function of olfactory receptors. Lidocaine alters the conformation of membrane proteins, and curcumin alters lipid raft composition, both affecting the cell membrane where OR9A2 is embedded. Dextromethorphan might indirectly modulate OR9A2 signaling by altering neurotransmitter levels, showcasing a diverse array of mechanisms by which these inhibitors can affect OR9A2 function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1,8-Cineole | 470-82-6 | sc-485261 | 25 ml | $43.00 | 2 | |
This compound is a known odorant that interacts with olfactory receptors such as OR9A2. It binds to the receptor's active site, preventing the binding of other odorant molecules, thus inhibiting signal transduction. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin is an agonist of TRPV1, a receptor that can modulate the olfactory receptor function. Activation of TRPV1 can lead to a decrease in cAMP levels, which may indirectly inhibit OR9A2 signaling. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $38.00 $67.00 | ||
Menthol is a compound that affects the function of various G-protein coupled receptors, including olfactory receptors. By altering the lipid membrane environment or receptor conformation, menthol can inhibit OR9A2 activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions can bind to olfactory receptors and stabilize them in an inactive conformation. This can prevent OR9A2 from activating and initiating a signal transduction cascade. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Similar to zinc, copper ions can interact with OR9A2 and other olfactory receptors, potentially leading to inhibition of their activity through conformational stabilization. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine is known to interfere with the glycosylation of membrane proteins, which may affect OR9A2 receptor expression and function, leading to diminished signaling. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
This compound is known to block ion channels and receptor-mediated signaling. It could indirectly affect OR9A2 by altering intracellular calcium levels necessary for olfactory signal transduction. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
Lidocaine is a local anesthetic that can affect membrane-bound proteins by altering their conformation or the lipid environment. It might inhibit OR9A2 indirectly by changing its structural dynamics. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin affects various signaling pathways and could inhibit OR9A2 by altering the lipid raft composition of the cell membrane where OR9A2 resides, thus affecting its function. | ||||||
Dextromethorphan | 125-71-3 | sc-278927 sc-278927A sc-278927B | 10 g 100 g 500 g | $174.00 $1133.00 $5106.00 | 3 | |
This antitussive agent can also act as a non-selective serotonin reuptake inhibitor, which may indirectly impact OR9A2 activity by altering neurotransmitter levels and affecting olfactory signal modulation. | ||||||