OR9A2 Activators
OR9A2 Activators are a set of chemical compounds that enhance the signaling and functional activity of the olfactory receptor OR9A2. Cinnamaldehyde, eugenol, and methyl salicylate each bind to OR9A2, mimicking the effect of natural odorants, which increases intracellular calcium levels or cAMP, leading to amplified neuronal activation. Similarly, ethyl vanillin and isoamyl acetate act as ligands for the receptor, stimulating a conformational change that favors signal transduction, thereby enhancing the sensitivity and signaling of olfactory pathways. Anethole and benzaldehyde selectively bind to OR9A2, functioning as agonists that elevate intracellular calcium signaling, and citral serves as an activator by inducing G-protein activation, all three contributing to stronger olfactory responses.
Further enhancing OR9A2 activity, geraniol, limonene, linalool, and vanillin each serve as potent ligands that interact with the active site of the receptor, promoting G-protein coupled receptor signaling through the classic olfactory transduction pathway. These activations result in an increase in intracellular cAMP and calcium levels, which are crucial for the olfactory signaling process, culminating in heightened sensory perception. By acting directly on OR9A2, these compounds induce specific ligand-receptor interactions that lead to an overall potentiation of the functional role of OR9A2 in olfaction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol acts directly on OR9A2 by binding to the receptor, which triggers an increase in intracellular cAMP, enhancing the receptor's sensitivity and signaling to olfactory neurons. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate is known to activate OR9A2 by binding to its ligand-binding domain, which leads to the activation of the olfactory signaling cascade and an enhanced sensory response. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
Ethyl vanillin activates OR9A2, simulating the presence of the natural aromatic ligand and initiating olfactory receptor neuron responses through increased cAMP levels. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isoamyl acetate serves as a ligand for OR9A2, enhancing receptor activity by inducing a conformational change that promotes signal transduction in olfactory pathways. | ||||||
Anethole | 104-46-1 | sc-481571A sc-481571 | 10 g 100 g | $576.00 $316.00 | ||
Anethole selectively activates OR9A2 by direct binding, which leads to downstream signaling events in olfactory neurons and an enhanced perception of anise-scented molecules. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral is an activator of OR9A2, binding to the receptor to induce olfactory G-protein activation and subsequent neuronal excitation. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol is a terpene that binds and activates OR9A2, leading to an increase in intracellular cAMP and calcium, potentiating the olfactory signaling process. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
Limonene interacts with OR9A2 by binding to its active site, promoting G-protein coupled receptor signaling and enhancing the overall olfactory response. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool acts as a ligand for OR9A2, facilitating receptor activation and subsequent olfactory neuron excitation through the classic olfactory transduction pathway. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $44.00 $124.00 | 1 | |
Vanillin directly activates OR9A2, which increases the receptor's ability to initiate the olfactory transduction cascade, resulting in a heightened sensory perception. | ||||||