OR8G5 Activators
OR8G5 include a variety of compounds that influence the signaling pathways leading to its activation. Forskolin is a direct stimulator of adenylyl cyclase, which catalyzes the conversion of ATP to cAMP. The rise in cAMP levels activates protein kinase A (PKA), which then phosphorylates OR8G5, resulting in its activation. Similarly, isoproterenol, a beta-adrenergic agonist, binds to beta-adrenergic receptors and enhances adenylyl cyclase activity, thereby increasing cAMP production. The cAMP, in turn, activates PKA, which phosphorylates and activates OR8G5. IBMX works in a slightly different manner; it is a non-selective inhibitor of phosphodiesterases, enzymes responsible for cAMP degradation. By preventing cAMP breakdown, IBMX indirectly elevates cAMP levels, thus facilitating PKA activation and subsequent phosphorylation of OR8G5.
PGE2 and histamine both activate G protein-coupled receptors that signal via adenylyl cyclase to increase intracellular cAMP levels, leading to the activation of PKA and the phosphorylation of OR8G5. Dopamine and epinephrine also promote OR8G5 activation through their interaction with specific G protein-coupled receptors that stimulate cAMP production. Glucagon, binding to its own receptor, similarly initiates a signaling cascade that results in elevated cAMP and PKA-mediated phosphorylation of OR8G5. Anisomycin activates stress-activated protein kinases, which may also lead to OR8G5 phosphorylation. Rolipram, inhibiting phosphodiesterase 4, raises cAMP levels, enabling PKA to phosphorylate and activate OR8G5. Lastly, salbutamol and terbutaline, which are selective beta2-adrenergic receptor agonists, increase intracellular cAMP, thereby activating PKA. The active PKA can then phosphorylate and activate OR8G5, completing the signal transduction process initiated by these chemical activators.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol, a beta-adrenergic agonist, binds to beta-adrenergic receptors and stimulates adenylyl cyclase activity, leading to increased cAMP production which in turn activates PKA. PKA activation can lead to OR8G5 activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which increases cAMP by preventing its breakdown. Elevated cAMP levels activate PKA, which may phosphorylate and activate OR8G5 as part of cAMP signal transduction. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) interacts with its G protein-coupled receptors, leading to increased intracellular cAMP levels. This can activate PKA, which then has the potential to activate OR8G5 through phosphorylation. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine can bind to H2 receptors, which are coupled to Gs proteins, leading to activation of adenylyl cyclase and increased cAMP levels. The cAMP produced can activate PKA, which may result in the activation of OR8G5. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can bind to dopamine D1-like receptors, leading to the activation of adenylyl cyclase and increased cAMP levels. This cAMP can activate PKA, which may then lead to the phosphorylation and activation of OR8G5. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine interacts with beta-adrenergic receptors, leading to increased cAMP and activation of PKA. PKA may then phosphorylate and activate OR8G5 within its signaling pathway. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases (SAPKs), which are involved in cellular responses to cytokines and stress. SAPKs can potentially phosphorylate and activate OR8G5. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), leading to an increase of cAMP in cells. The increased cAMP levels can activate PKA, and PKA can subsequently phosphorylate and activate OR8G5. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $94.00 $141.00 | ||
Salbutamol is a selective beta2-adrenergic receptor agonist that can increase intracellular cAMP by activating adenylyl cyclase. The cAMP activates PKA, which can lead to phosphorylation and activation of OR8G5 in the signaling pathway. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $92.00 $378.00 | 2 | |
Terbutaline activates beta2-adrenergic receptors, leading to an increase in cAMP levels. Elevated cAMP activates PKA, and PKA may then phosphorylate and activate OR8G5 as part of the adrenergic signaling cascade. | ||||||