OR56A4 Activators
OR56A4 initiate a cascade of intracellular events that culminate in the protein's activation. Forskolin, a direct stimulator of adenylyl cyclase, elevates cyclic AMP (cAMP) levels within the cell, which in turn activates protein kinase A (PKA). The activation of PKA is a critical step in the phosphorylation of OR56A4, preparing it for activation. This same pathway is engaged by other activators such as Isoproterenol, PGE2, Epinephrine, Histamine, Dopamine, Adenosine, Glucagon, Salbutamol, and Terbutaline. These compounds interact with various G-protein-coupled receptors, each specific to its ligand, but all ultimately leading to the activation of adenylyl cyclase. The increase in cAMP from these interactions stimulates PKA, which then targets OR56A4 to undergo phosphorylation.
Cholera toxin and IBMX operate through mechanisms that also result in the elevation of cAMP, albeit by different means. Cholera toxin achieves this by irreversibly activating the Gs alpha subunit, leading to sustained adenylyl cyclase activity and cAMP accumulation. IBMX, on the other hand, prevents the degradation of cAMP by inhibiting phosphodiesterases, which typically break down cAMP. The resultant rise in cAMP levels leads to the same activation of PKA, which is central to the phosphorylation state of OR56A4. These chemical agents, through their distinct interactions with cellular signaling pathways, ensure the activation of PKA, which then consistently targets OR56A4, facilitating its activation state.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is an agonist of beta-adrenergic receptors which, when bound, stimulate adenylyl cyclase activity, consequently raising cAMP levels. This increase in cAMP could activate PKA, potentially leading to the phosphorylation and activation of OR56A4. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) interacts with its G-protein-coupled receptors (GPCRs), which can activate adenylate cyclase, increase cAMP in the cell, and thereby activate PKA. PKA activation may result in the phosphorylation and activation of OR56A4. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to and activates beta-adrenergic receptors, which can stimulate adenylyl cyclase and increase intracellular cAMP levels. The subsequent activation of PKA could lead to phosphorylation and activation of OR56A4. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine can bind to H2 receptors that activate adenylyl cyclase, increasing cAMP levels and activating PKA. The activation of PKA may then contribute to the phosphorylation and activation of OR56A4. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine binds to D1-like receptors that activate adenylyl cyclase, increasing intracellular cAMP and activating PKA. PKA could potentially phosphorylate and activate OR56A4. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine interacts with A2 receptors, which stimulate adenylyl cyclase to increase cAMP levels, thereby activating PKA. Active PKA might phosphorylate and activate OR56A4. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes that break down cAMP. By preventing cAMP degradation, IBMX indirectly raises cAMP levels, which could activate PKA and lead to the activation of OR56A4. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $94.00 $141.00 | ||
Salbutamol is a beta-2 adrenergic receptor agonist, which stimulates adenylyl cyclase to raise cAMP levels, leading to PKA activation. PKA could then activate OR56A4. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $92.00 $378.00 | 2 | |
Terbutaline acts on beta-2 adrenergic receptors to stimulate adenylyl cyclase, increasing cAMP levels and activating PKA, which may phosphorylate and activate OR56A4. | ||||||