OR3A1 Activators
Forskolin directly stimulates adenylyl cyclase, leading to an uptick in cAMP levels, a critical secondary messenger that bolsters GPCR signaling and, consequently, OR3A1 receptor activity. Substances like IBMX, theophylline, caffeine, zaprinast, rolipram, and BAY 60-7550, function as phosphodiesterase inhibitors. Their role in impeding cAMP degradation results in heightened intracellular signaling strength, which has the potential to amplify OR3A1 receptor activation. Compounds like prostaglandin E2 engage with their specific GPCRs to elevate cAMP concentrations, which in turn may sway OR3A1 receptor signaling. This modulation reflects a common theme among these activators: the manipulation of cAMP levels, whether by promoting its production or preventing its breakdown, which serves as a pivotal point of control in the regulation of OR3A1.
Histamine and adenosine, each binding to their respective GPCRs, set off signaling cascades that result in increased cAMP or calcium levels, which can indirectly impinge on the operational dynamics of OR3A1. Isoproterenol, acting as a synthetic beta-adrenergic agonist, also boosts cAMP production, potentially leading to an upsurge in OR3A1 signaling. Glucagon further underscores this commonality, as it acts through its own GPCR to ratchet up cAMP levels, influencing OR3A1 activity in the process.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
A non-selective inhibitor of phosphodiesterases, preventing cAMP breakdown, which can indirectly increase OR3A1 activity. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $32.00 $85.00 | 6 | |
A phosphodiesterase inhibitor that can raise cAMP levels, thus potentially enhancing the signaling of OR3A1. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Similar to theophylline, as a phosphodiesterase inhibitor, caffeine can increase intracellular cAMP, affecting OR3A1. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 binds to its GPCR and can raise cAMP levels, influencing OR3A1 receptor activity. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Activates GPCRs that can increase intracellular calcium, which can modulate OR3A1 activity indirectly. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
A synthetic beta-adrenergic agonist that can stimulate cAMP production, potentially enhancing OR3A1 signaling. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Through its GPCRs, adenosine can increase cAMP, which can modulate OR3A1 activity. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
A phosphodiesterase inhibitor that increases cAMP levels and can enhance GPCR signaling, including OR3A1. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Inhibits phosphodiesterase-4, increasing cAMP concentration, potentially affecting OR3A1 signaling. | ||||||
Glucagon trifluoroacetic acid salt | 9007-92-5 (free base) | sc-495801 | 1 mg | $480.00 | ||
A hormone that acts through its GPCR to increase cAMP, which can affect OR3A1 activity. | ||||||