OR10A5 Activators
OR10A5 can initiate a cascade of intracellular events leading to its activation through various signaling pathways. Isoproterenol, by agonizing beta-adrenergic receptors, and Forskolin, by directly activating adenylyl cyclase, both result in elevated levels of cAMP within the cell. This rise in cAMP activates protein kinase A (PKA), which in turn has the capacity to phosphorylate OR10A5, assuming it is a substrate for this kinase. Similarly, Epinephrine and Salbutamol, through their interaction with adrenergic receptors, and Terbutaline, specifically targeting beta-2 adrenergic receptors, lead to the activation of adenylyl cyclase, culminating in increased cAMP and subsequent PKA activation, which may act on OR10A5. Histamine, through its receptors, and Dopamine, via its G-protein-coupled receptors, both have effects on cAMP levels and thus on PKA, which may then interact with OR10A5 if it is within the scope of PKA's phosphorylation targets.
Adenosine and PGE2 (Prostaglandin E2) engage with their respective G-protein-coupled receptors to modulate adenylyl cyclase activity, again influencing cAMP concentrations and PKA activity, providing another pathway for the activation of OR10A5. Glucagon also binds to its specific receptor to enhance cAMP and activate PKA, which may then target OR10A5. The phosphodiesterase inhibitors, IBMX and Rolipram, increase intracellular cAMP levels by preventing its degradation, which indirectly leads to PKA activation. PKA, once activated, can phosphorylate target proteins such as OR10A5, leading to its activation. These chemicals, through their distinct interactions with cellular signaling mechanisms, all converge on the pathway involving cAMP and PKA, which in turn can engage OR10A5, culminating in its activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is an agonist of the beta-adrenergic receptors, which can lead to the activation of adenylyl cyclase and an increase in cyclic AMP (cAMP) in various cell types. Elevated levels of cAMP can activate protein kinase A (PKA), which can phosphorylate and activate various cellular proteins, potentially including OR10A5 if it is regulated by PKA phosphorylation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, leading to an increase in intracellular cAMP concentrations. Increased cAMP activates PKA, which may phosphorylate and activate OR10A5 if it is a substrate for PKA. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine can bind to and activate G-protein-coupled histamine receptors, which can engage signaling cascades involving second messengers such as cAMP, potentially leading to the activation of OR10A5 through downstream effects of PKA. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine interacts with adrenergic receptors, which can initiate a signaling cascade resulting in the production of cAMP and activation of PKA. PKA could then phosphorylate and activate OR10A5 if its function is modulated by phosphorylation. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine binds to its G-protein-coupled receptors, potentially influencing intracellular levels of cAMP and the activity of PKA. If OR10A5 is a PKA substrate, it may be activated via PKA-mediated phosphorylation. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine interacts with its G-protein-coupled receptors, leading to various responses including the modulation of adenylyl cyclase activity and changes in cAMP levels. This could activate PKA, which in turn can activate OR10A5 if it is sensitive to PKA regulation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 binds to its G-protein-coupled E-prostanoid receptors, which can lead to an increase in intracellular cAMP and activation of PKA. This cascade could activate OR10A5 through PKA-dependent phosphorylation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes that break down cAMP. By preventing cAMP degradation, IBMX indirectly increases cAMP levels, potentially enhancing PKA activity and activating OR10A5 through phosphorylation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which hydrolyzes cAMP. Inhibition of PDE4 by Rolipram leads to increased cAMP levels, which could activate PKA and subsequently OR10A5 if it is a PKA substrate. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $92.00 $138.00 | ||
Salbutamol is a beta-2 adrenergic agonist that can increase intracellular cAMP by activating adenylyl cyclase through GPCR signaling. Increased cAMP activates PKA, which may activate OR10A5 through phosphorylation if it is within PKA's substrate scope. | ||||||