OPN1MW2 Activators
OPN1MW2 activators primarily function by influencing phototransduction, given the protein's role in this process. All-trans-retinal and 11-cis-retinal, forms of vitamin A, are integral to phototransduction. These compounds bind to OPN1MW2, allowing it to absorb light and undergo a conformational change. This change initiates an electrical signal cascade that results in the perception of color and light. Forskolin, IBMX, and caffeine, through their ability to increase cAMP levels, can enhance the opening of CNG channels, which are crucial for the phototransduction cascade. By doing so, they indirectly enhance the activity of OPN1MW2. The effect of OPN1MW2 activators extends to the regulatory realm of phototransduction as well. For instance, Zaprinast, Sildenafil, Tadalafil, and Vardenafil, through their inhibition of PDE5, increase cGMP levels, leading to the opening of CNG channels. This action enhances the phototransduction cascade indirectly influencing the functionality of OPN1MW2. Similarly, Papaverine, a nonspecific PDE inhibitor, increases both cAMP and cGMP levels, enhancing the phototransduction cascade and indirectly boosting the activity of OPN1MW2.
Additionally, the calcium channel blocker Nifedipine modulates intracellular calcium levels, which are necessary for the phototransduction cascade and can indirectly influence the functionality of OPN1MW2. Nitric Oxide donors such as Sodium Nitroprusside increase intracellular cGMP levels by activating guanylate cyclase. The increased cGMP can lead to the opening of CNG channels, which are necessary for the phototransduction cascade. Through the modulation of these signaling pathways, these chemicals can indirectly enhance the activity of the OPN1MW2 protein. The intricate biochemical interactions between these compounds and the associated cellular processes underscore the critical role of these OPN1MW2 activators in the biological system.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
all-trans Retinal | 116-31-4 | sc-210778A sc-210778 | 250 mg 1 g | $126.00 $372.00 | 7 | |
All-trans-retinal is a form of vitamin A that is necessary for the phototransduction cascade in cone cells. It binds to OPN1MW2, enabling it to absorb light and trigger a conformational change, which initiates the cascade that generates an electrical signal to the brain. | ||||||
11-cis Retinal | 564-87-4 | sc-208843 sc-208843A sc-208843B sc-208843C sc-208843D | 500 µg 1 mg 2 mg 10 mg 25 mg | $760.00 $1479.00 $2449.00 $12240.00 $26520.00 | 2 | |
11-cis-retinal is another form of vitamin A. It also binds to OPN1MW2 and is essential for the phototransduction cascade. It gets converted to all-trans-retinal upon light absorption, triggering the same cascade as mentioned above. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin can increase cyclic AMP levels by activating adenylate cyclase. The increase in cAMP can lead to the opening of CNG channels, which are essential for generating the electrical signal in the phototransduction cascade. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterase (PDE), which can increase cAMP levels. Higher cAMP levels can lead to the opening of CNG channels, amplifying the phototransduction cascade. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine is another nonspecific PDE inhibitor and can also increase cAMP levels, leading to the opening of CNG channels, which are crucial for the phototransduction cascade. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast is a PDE inhibitor, which specifically increases cGMP levels. Increased cGMP levels can also lead to the opening of CNG channels, enhancing the phototransduction cascade. | ||||||
Tadalafil | 171596-29-5 | sc-208412 | 50 mg | $176.00 | 13 | |
Tadalafil is another PDE5 inhibitor that increases cGMP levels. Increased cGMP can also open CNG channels, enhancing the phototransduction cascade. | ||||||
Vardenafil | 224785-90-4 | sc-362054 sc-362054A sc-362054B | 100 mg 1 g 50 g | $516.00 $720.00 $16326.00 | 7 | |
Vardenafil is a PDE5 inhibitor, increasing cGMP levels that lead to the opening of CNG channels, which are crucial for the phototransduction cascade. | ||||||
Papaverine | 58-74-2 | sc-279951 sc-279951A sc-279951B | 10 mg 50 mg 100 mg | $153.00 $265.00 $459.00 | ||
Papaverine is a nonspecific PDE inhibitor that can increase both cAMP and cGMP levels. The increase in these cyclic nucleotides can lead to the opening of CNG channels, enhancing the phototransduction cascade. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is a calcium channel blocker that can modulate the intracellular calcium levels, which is necessary for the phototransduction cascade and can indirectly influence the functionality of OPN1MW2. | ||||||