Olr74 Activators
Chemical activators of Olr74 can engage in a series of biochemical interactions that lead to its activation. Forskolin, a well-established activator of adenylate cyclase, can raise intracellular cAMP levels, thereby activating protein kinase A (PKA). Once activated, PKA can phosphorylate Olr74, leading to its functional activation. Similarly, isoproterenol, epinephrine, histamine, serotonin, dopamine, adenosine, prostaglandin E2, and glucagon all bind to their respective G-protein-coupled receptors (GPCRs), which are coupled to the Gs protein. The activation of these receptors by their ligands leads to the activation of adenylate cyclase, causing an increase in the levels of cAMP. As with forskolin, the elevated cAMP activates PKA, which then can phosphorylate and activate Olr74.
Additionally, caffeine and IBMX are known phosphodiesterase inhibitors, which prevent the breakdown of cAMP, maintaining its elevated concentration within the cell. This sustained high level of cAMP ensures that PKA remains active, and in turn, Olr74 remains in a state of activation by phosphorylation. BAY 60-6583 specifically activates adenosine A2B receptors, which also signal via Gs proteins to activate adenylate cyclase, leading to increased cAMP and subsequent PKA-mediated activation of Olr74. These chemical activators, through their distinct mechanisms, all converge on the pathway of cAMP and PKA to activate Olr74, demonstrating the central role of this signaling pathway in the regulation of Olr74 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol binds to beta-adrenergic receptors, causing a Gs protein-mediated activation of adenylate cyclase, raising cAMP levels and leading to the activation of Olr74 via PKA phosphorylation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine interacts with alpha and beta-adrenergic receptors, triggering adenylate cyclase activation through Gs protein signaling, increasing cAMP and activating Olr74 through PKA. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine binds H2 receptors, which engage Gs proteins and activate adenylate cyclase, boosting cAMP levels, and in turn, PKA activates Olr74. | ||||||
Serotonin hydrochloride | 153-98-0 | sc-201146 sc-201146A | 100 mg 1 g | $118.00 $187.00 | 15 | |
Serotonin acts on specific 5-HT receptors that stimulate adenylate cyclase, raise cAMP levels, and lead to the activation of Olr74 by PKA. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine binds to D1-like receptors, which are coupled to Gs proteins, promoting adenylate cyclase activity, increasing cAMP, and enabling PKA to activate Olr74. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine engages with A2 receptors, leading to adenylate cyclase activation via Gs proteins, the rise in cAMP levels, and subsequent activation of Olr74 by PKA. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 interacts with EP2/EP4 receptors, which signal through Gs proteins to activate adenylate cyclase, increase cAMP and activate Olr74 through PKA. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits phosphodiesterases, preventing the breakdown of cAMP, thus sustaining PKA activation, which can phosphorylate and activate Olr74. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX also inhibits phosphodiesterases, ensuring continued high levels of cAMP, thereby maintaining PKA activation and facilitating the activation of Olr74. | ||||||
BAY 60-6583 | 910487-58-0 | sc-503262 | 10 mg | $210.00 | ||
BAY 60-6583 selectively activates adenosine A2B receptors, enhancing adenylate cyclase activity, increasing cAMP, and leading to PKA-mediated activation of Olr74. | ||||||