Olr418 Activators
Chemical activators of Olr418 include a variety of compounds that influence intracellular signaling pathways, leading to the functional activation of this protein. Calcium chloride and Ionomycin, for instance, can activate Olr418 by increasing intracellular calcium levels, a crucial second messenger in many signaling cascades. Calcium chloride achieves this by providing an external source of calcium that enters cells, while Ionomycin acts as a calcium ionophore, facilitating the transport of calcium into the cellular milieu. Thapsigargin and BAY K8644 also promote the activation of Olr418 via modulation of intracellular calcium. Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump, leading to calcium accumulation within the cytosol, while BAY K8644 acts as a positive modulator of L-type calcium channels, further supporting the influx of calcium.
Zinc Pyrithione can activate Olr418 by altering intracellular zinc concentrations, which might directly bind to Olr418 or change its interaction with other regulatory molecules. Forskolin raises cAMP levels that subsequently activate protein kinase A (PKA), which in turn can phosphorylate Olr418 or proteins associated with its regulation. Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can then phosphorylate target proteins including Olr418. Okadaic Acid, by inhibiting phosphatases such as PP1 and PP2A, leads to an increase in the phosphorylation state of cellular proteins, which may include Olr418, thus promoting its activity. Anisomycin can activate stress-activated protein kinases which could phosphorylate Olr418. Ouabain and Veratridine can activate Olr418 by altering ion gradients; Ouabain by inhibiting the Na+/K+ ATPase pump and Veratridine by modifying sodium channel functions, which can influence various cellular signaling mechanisms. Lastly, Calyculin A, akin to Okadaic Acid, inhibits protein phosphatases to maintain proteins in a phosphorylated state, which can include Olr418, ensuring its active conformation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium chloride can activate Olr418 by increasing intracellular calcium levels, which may directly interact with the protein to induce conformational changes leading to its activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin can activate Olr418 by acting as an ionophore, selectively binding and transporting calcium ions into cells, raising intracellular calcium concentrations that could directly activate Olr418. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin can activate Olr418 through inhibition of the SERCA pump, resulting in elevated cytosolic calcium levels that may activate Olr418 by altering its conformation or interaction with calcium-sensitive domains. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
BAY K8644 can activate Olr418 by acting as an agonist at L-type calcium channels, which increases intracellular calcium and could lead to the activation of Olr418 through calcium-sensitive mechanisms. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc Pyrithione can activate Olr418 by increasing intracellular zinc concentrations, which may bind to Olr418 or modify its interaction with regulatory proteins or ions, leading to activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA can activate Olr418 by activating PKC, which may phosphorylate Olr418 or related proteins, altering interactions and leading to activation of Olr418. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid can activate Olr418 by inhibiting protein phosphatases 1 and 2A, leading to an increase in phosphorylated proteins, which could include Olr418 or proteins that regulate Olr418 activity, thus promoting its activation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin can activate Olr418 by stimulating stress-activated protein kinases, which could phosphorylate Olr418 or associated regulatory proteins, leading to its activation. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $516.00 | |||
Ouabain can activate Olr418 by inhibiting the Na+/K+ ATPase pump, which alters ion gradients and cellular signaling pathways that could lead to the activation of Olr418. | ||||||
Veratridine | 71-62-5 | sc-201075B sc-201075 sc-201075C sc-201075A | 5 mg 10 mg 25 mg 50 mg | $82.00 $104.00 $201.00 $379.00 | 3 | |
Veratridine can activate Olr418 by modifying sodium channel function, which could lead to changes in cellular excitability and signaling pathways, resulting in the activation of Olr418. | ||||||