Molecular structure of Veratridine, CAS Number: 71-62-5
Veratridine (CAS 71-62-5)
See product citations (3)
Application:
Veratridine is a voltage dependent Na+ channel opening agent
CAS Number:
71-62-5
Purity:
≥98%
Molecular Weight:
673.8
Molecular Formula:
C36H51NO11
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Veratridine is an agent that opens voltage dependent Na+ channels, blocks Na+ channel activation, and induces Ca2+ influx. The compound has been observed to be an alkaloid neurotoxin used to amplify sodium permeability. Studies report that Veratridine can trigger exocytosis and induce Ca2+ oscillations. Furthermore, Veratridine may act to effect the mitochondrial respiratory chain complexes, induce release of noradrenaline, and increase superoxide anion production.
Veratridine (CAS 71-62-5) References
- Alteration of veratridine neurotoxicity in sympathetic neurons during development in vitro. | Koike, T. and Ninomiya, T. 2000. Neuroreport. 11: 151-5. PMID: 10683848
- Veratridine induces apoptotic death in bovine chromaffin cells through superoxide production. | Jordán, J., et al. 2000. Br J Pharmacol. 130: 1496-504. PMID: 10928950
- Excessive release of [3H] noradrenaline by veratridine and ischemia in spinal cord. | Sumiya, Y., et al. 2001. Neurochem Int. 39: 59-63. PMID: 11311450
- The regulation of veratridine-stimulated electrogenic ion transport in mouse colon by neuropeptide Y (NPY), Y1 and Y2 receptors. | Hyland, NP. and Cox, HM. 2005. Br J Pharmacol. 146: 712-22. PMID: 16100526
- Effects of veratrine and veratridine on oxygen consumption and electrical membrane potential of isolated rat skeletal muscle and liver mitochondria. | Silva Freitas, EM., et al. 2006. Toxicon. 47: 780-7. PMID: 16626771
- Kinetics of veratridine action on Na channels of skeletal muscle. | Sutro, JB. 1986. J Gen Physiol. 87: 1-24. PMID: 2419478
- Voltage-dependent gating of veratridine-modified Na channels. | Leibowitz, MD., et al. 1986. J Gen Physiol. 87: 25-46. PMID: 2419480
- Rapid and slow gating of veratridine-modified sodium channels in frog myelinated nerve. | Rando, TA. 1989. J Gen Physiol. 93: 43-65. PMID: 2536798
- Veratridine modifies the gating of human voltage-gated sodium channel Nav1.7. | Zhang, XY., et al. 2018. Acta Pharmacol Sin. 39: 1716-1724. PMID: 29950616
- Veratridine binding to a transmembrane helix of sodium channel Nav1.4 determined by solid-state NMR. | Niitsu, A., et al. 2018. Bioorg Med Chem. 26: 5644-5653. PMID: 30389410
- Veratridine: A Janus-Faced Modulator of Voltage-Gated Sodium Ion Channels. | Craig, RA., et al. 2020. ACS Chem Neurosci. 11: 418-426. PMID: 31951114
- Purification, solubility, and pKa of veratridine. | McKinney, LC., et al. 1986. Anal Biochem. 153: 33-8. PMID: 3963380
- Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine. | Maroto, R., et al. 1994. Eur J Pharmacol. 270: 331-9. PMID: 7805782
- Veratridine triggers exocytosis in Paramecium cells by activating somatic Ca channels. | Plattner, H., et al. 1994. J Membr Biol. 142: 229-40. PMID: 7884815
- Involvement of different calcium channels in K+- and veratridine-induced increases of cytosolic calcium concentration in rat cerebral cortical synaptosomes. | Meder, W., et al. 1997. Naunyn Schmiedebergs Arch Pharmacol. 356: 797-805. PMID: 9453466
Inhibitor of:
Complexin-4, Na+ CP type IIIβ, sodium channel type II, sodium channel type IV, and Unc79.Activator of:
ANKRD36–Ankrd36, ASIC2, ATP8A2, CAPS-1, CatSperγ, FAM40B, KCTD7, KV3.1, MrgA3, Na+ CP type Iβ, Na+ CP type IIα, Na+ CP type IVα, Na+ CP type IXα, Na+ CP type Vα, Na+ CP type VIIα, Na+ CP type Xα, Na+ CP type XIα, Na+/K+ ATPase β4, NALCN, NaS-1, NKAIN4, Olr367, Olr374, Olr382, Olr395, Olr401, Olr404, Olr409, Olr413, Olr418, Olr420, Olr424, Olr437, Olr443, Olr463, Olr482, Olr484, Olr496, Olr507, Olr516, Olr526, Olr532, Olr541, Olr552, Olr556, Olr559, Olr561, Olr575, Olr592, Olr601, Olr608, Olr611, Olr619, Olr634, Olr639, Olr653, Olr657, Olr665, Olr672, Olr690, Olr696, Olr704, Olr709, Olr712, Olr716, Olr724, Olr727, Olr733, Olr736, Olr742, Olr747, Olr749, Olr766, Olr769, Olr773, Olr785, Olr791, Olr80, Olr806, Olr81, Olr831, Olr836, Olr853, Olr879, Olr905, Olr920, Olr951, Olr962, Olr982, OR2AP1, OR8U9, PATE-G, PREP, REEP2, SCNM1, SLC24A1, sodium channel type I, sodium channel type II, sodium channel type III, sodium channel type IV, SV2B, Unc79, VAChT, and Vmn1r104.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Veratridine, 5 mg | sc-201075B | 5 mg | $80.00 | |||
Veratridine, 10 mg | sc-201075 | 10 mg | $102.00 | |||
Veratridine, 25 mg | sc-201075C | 25 mg | $197.00 | |||
Veratridine, 50 mg | sc-201075A | 50 mg | $372.00 |