Olfr9 Inhibitors
Olfr9, a member of the olfactory receptor family in Mus musculus (house mouse), serves as a critical component of the olfaction process. These olfactory receptors belong to the G-protein-coupled receptor (GPCR) superfamily and possess a 7-transmembrane domain structure. Olfr9 functions as a molecular sensor, detecting odorant molecules within the nasal environment and initiating a complex signaling cascade that ultimately leads to the perception of specific odors. The inhibition of Olfr9 is achieved through the modulation of key elements within the olfactory signaling pathway. While direct inhibitors targeting Olfr9 may be limited, indirect inhibition is accomplished by influencing various components of the pathway. Chemical compounds such as forskolin, thapsigargin, LY294002, H-89, and others indirectly impact Olfr9 by targeting signaling cascades related to intracellular cyclic AMP (cAMP) levels, calcium concentrations, protein kinases, and more. These compounds disrupt olfactory receptor signaling pathways, potentially leading to the down-regulation of Olfr9-mediated signal transduction and affecting the perception of specific odors in house mice.
The intricate interplay of these inhibitors with the complex signaling networks associated with olfaction highlights the dynamic nature of olfactory perception and the potential for precise modulation of Olfr9 and related receptors. Understanding the mechanisms of Olfr9 inhibition provides valuable insights into the intricacies of olfactory signal processing in the house mouse, shedding light on the fascinating world of sensory perception.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the endoplasmic reticulum Ca2+-ATPase, leading to elevated intracellular calcium levels. Indirectly, it can affect Olfr9 by modulating calcium-dependent signaling pathways, potentially influencing olfactory receptor function and the perception of specific odors. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a phosphatidylinositol 3-kinase (PI3K) inhibitor, indirectly affecting Olfr9 by disrupting PI3K-mediated signaling pathways. This may lead to the down-regulation of olfactory receptor function and the modulation of odor perception. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, indirectly influencing Olfr9 by targeting the MAPK pathway. By disrupting this pathway, it may affect Olfr9 function indirectly, as MAPK signaling has connections with olfactory receptor signaling, potentially leading to changes in receptor function and odor perception. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $21.00 $65.00 $120.00 $251.00 $815.00 | 23 | |
EGTA is a calcium chelator that can indirectly inhibit Olfr9 by binding and sequestering extracellular calcium ions. This action disrupts calcium-dependent signaling pathways, potentially affecting olfactory receptor function and the perception of specific odors. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a phosphoinositide 3-kinase (PI3K) inhibitor, indirectly affecting Olfr9 by interfering with PI3K-mediated signaling pathways. This can lead to the down-regulation of olfactory receptor function and the modulation of odor perception. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 inhibits calmodulin-dependent protein kinase II (CaMKII), indirectly influencing Olfr9 by blocking CaMKII activity. This inhibition can disrupt olfactory receptor signaling pathways, potentially leading to the down-regulation of Olfr9-mediated signal transduction and odor perception. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Ryanodine is an inhibitor of ryanodine receptors, indirectly impacting Olfr9 by modulating calcium release from intracellular stores. This action can influence calcium-dependent signaling pathways associated with olfactory receptor function, potentially affecting odor perception. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor, indirectly affecting Olfr9 by disrupting tyrosine kinase-mediated signaling pathways. This can lead to the down-regulation of olfactory receptor function and the modulation of odor perception. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF-96365 is a blocker of store-operated calcium channels, indirectly influencing Olfr9 by modulating calcium influx. This action can disrupt calcium-dependent signaling pathways associated with olfactory receptor function, potentially affecting odor perception. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that can indirectly inhibit Olfr9 by facilitating the transport of calcium ions across membranes. This action can impact calcium-dependent signaling pathways involved in olfactory receptor function, potentially influencing odor perception. | ||||||