Olfr891 Inhibitors
Olfr891, a member of the olfactory receptor family in Mus musculus (house mouse), serves a crucial role in the initial stages of olfaction. These olfactory receptors, including Olfr891, are integral to the detection of odorant molecules in the nasal environment, setting in motion a complex cascade of events that eventually lead to the perception of specific smells. Olfr891 shares the structural characteristics of olfactory receptors, characterized by a 7-transmembrane domain, and it belongs to the family of G-protein-coupled receptors (GPCRs) that are encoded by single coding-exon genes. In the olfactory system, Olfr891, like its counterparts, interacts with odorant molecules, initiating a neuronal response. This interaction triggers a series of intracellular events, ultimately leading to the generation of neural impulses that are transmitted to the brain, where the perception of odors occurs. The olfactory receptor gene family, including Olfr891, represents the largest gene family in the mouse genome, underlining the importance of odor perception for the survival and behavior of these organisms.
Inhibition of Olfr891 primarily occurs through the modulation of critical components within the olfactory signaling pathway. While direct inhibitors specifically binding to Olfr891 may be limited, indirect inhibition is achieved by targeting elements of the pathway. Chemical compounds can influence Olfr891 function by acting on key components, such as adenylyl cyclase, kinases like PKA, calcium channels, MAPK pathways, and phospholipase C (PLC). These compounds indirectly disrupt olfactory receptor signaling, potentially leading to down-regulation of Olfr891 function and affecting the perception of specific odors in house mice. The complex interplay of these inhibitors with the intricate signaling networks associated with olfaction highlights the dynamic nature of olfactory perception and the potential for targeted modulation of Olfr891 and related receptors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is known to activate adenylyl cyclase, increasing intracellular cAMP levels. It indirectly influences Olfr891 by enhancing the cAMP-mediated signaling pathway, potentially amplifying olfactory responses and affecting the receptor's function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a potent MEK inhibitor that can indirectly modulate the MAPK pathway. By targeting this pathway, it may affect Olfr891 indirectly, as MAPK signaling has crosstalk with olfactory receptor signaling, potentially leading to changes in the receptor's function and odor perception. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Bay K8644 is a calcium channel agonist, and its antagonist counterpart can block calcium channels. By inhibiting calcium influx, it indirectly disrupts olfactory receptor signaling, potentially down-regulating Olfr891 function and the perception of specific odors. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $93.00 $356.00 | 13 | |
SQ 22536 is an adenylate cyclase inhibitor, indirectly influencing Olfr891 by reducing cAMP production. Inhibition of adenylate cyclase can lead to down-regulation of Olfr891-mediated signal transduction and odor perception. | ||||||
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $133.00 | 20 | |
KN-62 is a potent inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). Its indirect impact on Olfr891 may occur by inhibiting CaMKII, potentially influencing olfactory receptor signaling and the receptor's response to specific odors. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
Pertussis Toxin is known to inhibit G-protein signaling, including the type of G proteins involved in olfactory receptor signaling. By blocking G protein activity, it may indirectly down-regulate Olfr891 function and affect the perception of specific odors. | ||||||
Phytic acid solution | 83-86-3 | sc-205806 sc-205806A | 100 ml 500 ml | $148.00 $505.00 | ||
Phytic acid solution is a naturally occurring molecule that can influence cellular signaling, including pathways related to olfactory receptors. Its effects on intracellular signaling may indirectly affect Olfr891 function and odor perception by interfering with specific signaling events. | ||||||
Gallein | 2103-64-2 | sc-202631 | 50 mg | $83.00 | 20 | |
Gallein is a G protein-coupled receptor (GPCR) inhibitor that can indirectly modulate olfactory receptor signaling by affecting GPCR function. By interfering with GPCR signaling pathways, it may have an impact on Olfr891 and odor perception by disrupting downstream events in the receptor's signaling cascade. | ||||||