Olfr891 Activators
Olfr891 is an olfactory receptor protein responsible for detecting and transducing odorant signals, allowing us to perceive and differentiate various scents in our environment. Activation of Olfr891 involves a complex interplay of chemicals and signaling pathways that collectively contribute to its functional role in odor detection. The primary function of Olfr891 is to recognize and respond to specific odorants. When an odorant molecule binds to Olfr891, it undergoes a conformational change that activates the receptor. This activation can occur through direct binding of chemicals like 2-Isobutylthiazole and Dihydrogen sulfide to Olfr891's receptor site, or indirectly through the modulation of intracellular pathways like the cAMP-dependent PKA pathway by chemicals like 8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) and Resveratrol.
Indirect activators, such as Retinoic acid and Thapsigargin, influence Olfr891 by up-regulating its expression through specific signaling pathways. These chemicals enhance the synthesis of Olfr891 protein, resulting in an increased number of active receptors on the cell membrane and functional enhancement of odorant sensitivity. In summary, Olfr891 plays a crucial role in our sense of smell, and its activation is orchestrated by a diverse range of chemicals that either directly or indirectly enhance its responsiveness to odorants, allowing us to perceive and distinguish various scents in our environment.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) indirectly activates Olfr891 by mimicking cAMP. It enhances cAMP-dependent protein kinase (PKA) phosphorylation of olfactory receptors, amplifying their sensitivity to odorants and promoting the functional activation of Olfr891 in odor detection. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-glucose influences Olfr891 activation through the glycolytic pathway. It modulates glucose metabolism, indirectly enhancing olfactory receptor expression, leading to an amplification of the receptor's response to odorant molecules and functional activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol indirectly activates Olfr891 by influencing the SIRT1 signaling pathway. It up-regulates the expression of SIRT1, which in turn leads to increased Olfr891 expression. This results in an enhanced number of active receptors on the cell membrane and functional enhancement of odorant sensitivity. | ||||||
Allyl isothiocyanate | 57-06-7 | sc-252361 sc-252361A sc-252361B | 5 g 100 g 500 g | $43.00 $66.00 $117.00 | 3 | |
Allyl isothiocyanate directly activates Olfr891 by binding to its receptor site, inducing a conformational change that triggers intracellular signaling cascades through G-proteins, ultimately leading to the functional activation of Olfr891 in olfactory signal transduction. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin directly activates Olfr891 by binding to its receptor site, initiating a conformational change that triggers intracellular signaling cascades through G-proteins. This leads to the functional activation of Olfr891 in olfactory signal transduction. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid is an indirect activator of Olfr891. It influences the retinoic acid receptor signaling pathway, which in turn up-regulates Olfr891 expression by binding to retinoic acid response elements in its promoter region. This results in an increased number of active receptors on the cell membrane and functional enhancement of odorant sensitivity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin indirectly activates Olfr891 by inhibiting the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) pump. This leads to elevated intracellular calcium levels, which enhance olfactory receptor sensitivity and promote the functional activation of Olfr891 in response to odorants. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isoamyl acetate directly activates Olfr891 by binding to its receptor site, inducing a conformational change that triggers intracellular signaling cascades through G-proteins, ultimately leading to the functional activation of Olfr891 in olfactory signal transduction. | ||||||