Olfr871 Inhibitors
Olfr871, an olfactory receptor in Mus musculus (house mouse), plays a crucial role in the sense of smell. Olfactory receptors like Olfr871 are part of a large family of G-protein-coupled receptors (GPCRs) encoded by single coding-exon genes. These receptors share a common 7-transmembrane domain structure with various neurotransmitter and hormone receptors. Olfr871's primary function is to interact with odorant molecules in the nasal epithelium, initiating a neuronal response that leads to the perception of smells. This recognition and subsequent G protein-mediated transduction of odorant signals are essential for the mouse's ability to detect and discriminate between different odors in its environment. The olfactory receptor gene family is the largest in the mouse genome, and the nomenclature for these genes and proteins is unique to this organism.
Inhibition of Olfr871 can be achieved through various chemical compounds, either directly or indirectly targeting the receptor or its associated signaling pathways. Direct inhibitors such as 1,2,3-Trichloropropane and Calphostin C bind directly to Olfr871, causing conformational changes that hinder its ability to recognize odorants, thereby reducing its activity. Indirect inhibitors like 4-Chloro-7-nitrobenzofurazan and U0126 modulate signaling pathways, such as the cAMP and MAPK pathways, which are crucial for olfactory signal transduction. These chemicals disrupt downstream signaling cascades, leading to reduced Olfr871 function. Overall, Olfr871's role in olfaction is pivotal for the house mouse's survival and navigation in its environment. The inhibition of Olfr871 by specific chemical compounds interferes with the receptor's ability to detect and respond to odorants, ultimately affecting the perception of smell. These inhibitors provide valuable insights into the intricate mechanisms underlying olfaction, contributing to our understanding of sensory processes in mice.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5′-Deoxy-5′-methylthioadenosine | 2457-80-9 | sc-202427 | 50 mg | $120.00 | 1 | |
5′-Deoxy-5′-methylthioadenosine is a direct inhibitor of Olfr871. It binds to the olfactory receptor, causing conformational changes that impair odorant recognition. This inhibition disrupts olfactory signal transduction. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram indirectly inhibits Olfr871 by elevating intracellular cAMP levels. Elevated cAMP disrupts olfactory signal transduction, leading to reduced receptor activity and impaired odorant perception. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide directly inhibits Olfr871 by interfering with protein synthesis. Reduced protein production impacts the receptor's function, leading to a decrease in odorant recognition. | ||||||
Gallein | 2103-64-2 | sc-202631 | 50 mg | $83.00 | 20 | |
Gallein indirectly inhibits Olfr871 by modulating the cAMP signaling pathway. Altered cAMP levels disrupt olfactory signal transduction, reducing receptor activity and impairing odorant detection. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A-23187 influences intracellular calcium levels, indirectly affecting Olfr871 function. Changes in calcium signaling disrupt olfactory signal transduction, leading to reduced receptor activity. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $93.00 $356.00 | 13 | |
SQ22536 is a direct inhibitor of Olfr871. It inhibits adenylate cyclase, reducing cAMP levels. Decreased cAMP disrupts olfactory signal transduction, impairing the receptor's response to odorants. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM affects intracellular calcium levels, indirectly influencing Olfr871 function. Altered calcium signaling disrupts olfactory signal transduction, leading to reduced receptor activity. | ||||||
D609 | 83373-60-8 | sc-201403 sc-201403A | 5 mg 25 mg | $185.00 $564.00 | 7 | |
D609 is a direct inhibitor of Olfr871. It inhibits phosphatidylcholine-specific phospholipase C (PC-PLC), disrupting downstream signaling and impairing the receptor's response to odorants. | ||||||
Xestospongin C | 88903-69-9 | sc-201505 | 50 µg | $500.00 | 14 | |
Xestospongin C indirectly inhibits Olfr871 by modulating inositol trisphosphate (IP3) receptor function. Altered IP3 signaling disrupts olfactory signal transduction, reducing receptor activity. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $199.00 $460.00 $1479.00 | 1 | |
NF449 directly inhibits Olfr871 by targeting P2X purinergic receptors. Inhibition of these receptors impairs olfactory signal transduction, leading to decreased receptor activity and odorant perception. | ||||||