Olfr823 Inhibitors
Olfr823 is part of the olfactory receptor family, a subset of G-protein-coupled receptors (GPCRs) essential for the detection of odorants and the subsequent olfactory signal transduction. These receptors, including Olfr823, are specialized in their function, binding to specific odorant molecules and initiating a cascade of intracellular events leading to the perception of smell. The precise molecular interactions in this process are integral to the olfactory function. Given the absence of known direct inhibitors for Olfr823, the potential for indirect inhibition is considered through various mechanisms. These receptors are subject to regulation at multiple levels, including gene expression, protein modification, receptor trafficking, and signal transduction pathways. Chemicals that affect these regulatory processes can serve as indirect inhibitors of Olfr823.
The chemicals listed above target different aspects of cellular function that could indirectly impact Olfr823. For instance, compounds affecting ion channel activity and neurotransmitter levels can modify the neuronal environment, thereby influencing the function of olfactory receptors. Others, acting on metabolic or inflammatory pathways, can change the cellular context within which these receptors operate, potentially affecting their expression or signaling efficiency. The inhibition of Olfr823 by these chemicals is not through a direct interaction with the receptor but via broader cellular or systemic mechanisms that affect the receptor's function. Understanding these potential mechanisms of inhibition provides insights into the complex regulation of olfactory receptors. It underscores the diversity of approaches that can be taken to modulate the activity of receptors like Olfr823. The exploration of these indirect inhibitors highlights the intricate nature of olfactory receptor regulation and the nuanced understanding required to influence these receptors' function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin, a biguanide class drug, primarily inhibits hepatic gluconeogenesis. Its indirect effect on olfactory receptors like Olfr823 could involve altering metabolic pathways, which might influence olfactory receptor expression or function. | ||||||
Atropine | 51-55-8 | sc-252392 | 5 g | $200.00 | 2 | |
Atropine, a muscarinic acetylcholine receptor antagonist, impacts cholinergic signaling. This could indirectly influence Olfr823 by modulating acetylcholine-mediated modulation of olfactory pathways. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine, a calcium channel blocker, affects calcium ion dynamics. This could indirectly affect Olfr823 function by modulating the calcium-dependent processes in olfactory receptor neurons. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride, a sodium channel blocker, potentially alters ion flux across cell membranes. This can indirectly affect olfactory signaling, including the function of Olfr823, by changing the ionic environment of olfactory receptor neurons. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole, a cytochrome P450 inhibitor, can affect various metabolic and biosynthetic pathways. This might indirectly influence Olfr823 by altering the metabolic profile of olfactory neurons. | ||||||
Gabapentin | 60142-96-3 | sc-201481 sc-201481A sc-201481B | 20 mg 100 mg 1 g | $52.00 $92.00 $132.00 | 7 | |
Gabapentin, a GABA analogue, affects neurotransmission. This could indirectly impact Olfr823 by modulating neurotransmitter levels and their effect on olfactory receptor neurons. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc sulfate, known for its role in enzyme regulation, can modulate various biochemical pathways. This may indirectly influence Olfr823 by affecting enzyme activities crucial for olfactory signaling. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $52.00 $86.00 | 6 | |
Ibuprofen, a nonsteroidal anti-inflammatory drug, impacts prostaglandin synthesis. This could indirectly affect Olfr823 by altering the inflammatory response in olfactory tissues. | ||||||
(±)-Baclofen | 1134-47-0 | sc-200464 sc-200464A | 1 g 5 g | $55.00 $253.00 | ||
Baclofen, a GABA-B receptor agonist, modulates neurotransmitter release. This might influence Olfr823 indirectly by affecting GABAergic signaling in the olfactory system. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
Theophylline, a phosphodiesterase inhibitor, increases intracellular cAMP levels. This may indirectly affect Olfr823 by modulating cAMP-dependent pathways in olfactory receptor neurons. | ||||||