Molecular structure of (±)-Baclofen, CAS Number: 1134-47-0
(±)-Baclofen (CAS 1134-47-0)
Alternate Names:
4-Amino-3-(4-chlorophenyl)butanoic acid; Lioresal; (± )-beta-(Aminomethyl)-4-chlorobenzenepropanoic acid
Application:
(±)-Baclofen is a selective agonist of the GABAB receptor
CAS Number:
1134-47-0
Purity:
98%
Molecular Weight:
213.66
Molecular Formula:
C10H12ClNO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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(±)-Baclofen is prominently used in neurological research, particularly for studying its effects on GABA receptors, which are essential for understanding inhibitory neurotransmission in the brain. It acts as an agonist at GABA-B receptors, providing useful for dissecting the role of these receptors in modulating neural activity. Research involving (±)-Baclofen frequently focuses on its ability to influence synaptic plasticity, which is fundamental for learning and memory processes. Additionally, (±)-Baclofen is utilized in studies examining the regulation of neurotransmitter release, aiding in the exploration of mechanisms that control excitatory and inhibitory balance within the central nervous system. This compound is also used in research aimed at understanding muscle relaxation at the spinal level, exploring how modulation of synaptic transmission can influence motor control.
(±)-Baclofen (CAS 1134-47-0) References
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- Cloning and functional expression of GABA(B) receptors from Drosophila. | Mezler, M., et al. 2001. Eur J Neurosci. 13: 477-86. PMID: 11168554
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- GABAB receptor: a site of therapeutic benefit. | Bowery, NG. 2006. Curr Opin Pharmacol. 6: 37-43. PMID: 16361115
- 3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies. | Berthelot, P., et al. 1991. J Med Chem. 34: 2557-60. PMID: 1652022
- GABAB receptors as drug targets to treat gastroesophageal reflux disease. | Lehmann, A. 2009. Pharmacol Ther. 122: 239-45. PMID: 19303900
- Is the antispastic action of baclofen mediated by GABAB receptors? GABAB receptors and spasticity. | Wüllner, U. and Klockgether, T. 1990. Trends Pharmacol Sci. 11: 103. PMID: 1966568
- Historical perspective and emergence of the GABAB receptor. | Bowery, NG. 2010. Adv Pharmacol. 58: 1-18. PMID: 20655476
- GABAB receptors and their significance in mammalian pharmacology. | Bowery, N. 1989. Trends Pharmacol Sci. 10: 401-7. PMID: 2559518
- Effect of continuous intrathecal baclofen therapy in children: a systematic review. | Buizer, AI., et al. 2019. Dev Med Child Neurol. 61: 128-134. PMID: 30187921
- The Use of Baclofen as a Treatment for Alcohol Use Disorder: A Clinical Practice Perspective. | de Beaurepaire, R., et al. 2018. Front Psychiatry. 9: 708. PMID: 30662411
- Baclofen as an adjuvant therapy for autism: a randomized, double-blind, placebo-controlled trial. | Mahdavinasab, SM., et al. 2019. Eur Child Adolesc Psychiatry. 28: 1619-1628. PMID: 30980177
- Telescoped Continuous Flow Synthesis of Optically Active γ-Nitrobutyric Acids as Key Intermediates of Baclofen, Phenibut, and Fluorophenibut. | Ötvös, SB., et al. 2020. Org Lett. 22: 8122-8126. PMID: 33026815
- Efficacy and tolerability of baclofen in a U.S. community population with alcohol use disorder: a dose-response, randomized, controlled trial. | Garbutt, JC., et al. 2021. Neuropsychopharmacology. 46: 2250-2256. PMID: 34155332
- A physiological role for GABAB receptors and the effects of baclofen in the mammalian central nervous system. | Misgeld, U., et al. 1995. Prog Neurobiol. 46: 423-62. PMID: 8532848
Inhibitor of:
AZ2, C6orf192, Caytaxin, GABA T-2, IGSF9, LRFN5, melanopsin, MrgB4, NCDN, Neu, Neuritin, Olfr740, Olfr823, Olr1413, PCP-2, Rit2, RTP4, SAPAP2, SEZ6L2, Shank2, SLC38A8, Slc6a16, SLC7A12, SLITRK5, V1RB4, and Vmn2r20.Activator of:
ALS2CR11, Fox-1, GABA Receptor, GABA T-1, GABA T-3, GABAA R α 3, GABAA R α 4, GABAB R1, GABAB R1β, GABAB R2, GABAC Rρ1, Galanin, Gephyrin, GluR-δ2, GlyR α4, Grid2ip, KCNF1, KCTD12, Leu-enkephalin, LGI2, LRRTM2, mGluR-7, MrgA3, NP2, NPSF, PCP4L1, PICK1, PNKD, PNMAL1, PREP, PSD2, Relaxin 3, SAPAP2, SEZ6L, SHISA7, SHISA8, SLC7A6, SLITRK1, SLITRK5, Spatacsin, SRPX2, SV2A, Syntaphilin, Syntaxin 1, and Unc18-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-Baclofen, 1 g | sc-200464 | 1 g | $55.00 | |||
(±)-Baclofen, 5 g | sc-200464A | 5 g | $253.00 |