Olfr763 Inhibitors
Olfr763, a member of the olfactory receptor gene family in Mus musculus (house mouse), plays a pivotal role in the perception of odors. These olfactory receptors, classified as G-protein-coupled receptors (GPCRs), are characterized by a 7-transmembrane domain structure, similar to many neurotransmitter and hormone receptors. Olfr763 functions by interacting with odorant molecules in the nose, initiating neuronal responses that result in the perception of smells. The olfactory receptor gene family represents the largest gene family within the mouse genome, and their nomenclature is specific to this organism.
Inhibition of Olfr763 can be achieved through various mechanisms, primarily targeting critical signaling pathways. These pathways encompass calcium channels, cAMP signaling, the p38 MAPK pathway, ATP-gated P2X3 receptors, and intracellular calcium signaling. Additionally, specific inhibitors affect protein kinase A (PKA) and modulate inositol trisphosphate receptors (IP3Rs). By interfering with these pathways or cellular processes, Olfr763's function is compromised. This disruption ultimately leads to reduced sensitivity to odorant molecules, inhibiting its role in the perception of smells. Understanding Olfr763 and its inhibition contributes to unraveling the complexities of olfactory signal transduction in mice. Such research aids in advancing our comprehension of olfactory receptor function and regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF-96365 inhibits Olfr763 by blocking calcium channels, disrupting intracellular calcium signaling. This reduction in intracellular calcium levels leads to decreased sensitivity of Olfr763 to odorant molecules, ultimately inhibiting its function. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $95.00 $363.00 | 13 | |
SQ22536 indirectly inhibits Olfr763 by targeting the cAMP signaling pathway. It inhibits adenylate cyclase, reducing cAMP levels and disrupting the downstream activation of Olfr763, ultimately inhibiting the gene. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $31.00 $128.00 $454.00 | 45 | |
SB202190 inhibits p38 MAPK, a component of the MAPK pathway downstream of Olfr763. This disruption hinders the activation of transcription factors essential for Olfr763 expression, indirectly inhibiting the gene. | ||||||
NNC 55-0396 | 357400-13-6 | sc-203647A sc-203647 | 5 mg 10 mg | $250.00 $421.00 | 2 | |
NNC 55-0396 inhibits Olfr763 by targeting the ATP-gated P2X3 receptor, a crucial component in olfactory signal transduction. This blockade reduces downstream activation of Olfr763, inhibiting its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 inhibits the MAPK pathway downstream of Olfr763. This disruption hinders the activation of transcription factors necessary for Olfr763 expression, indirectly inhibiting the gene. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM inhibits Olfr763 by blocking intracellular calcium signaling. It is a cell-permeable calcium chelator that reduces calcium mobilization, leading to decreased sensitivity of Olfr763 to odorant molecules and inhibiting its function. | ||||||
SC514 | 354812-17-2 | sc-205504 sc-205504A | 5 mg 10 mg | $67.00 $91.00 | 13 | |
SC-514 inhibits p38 MAPK, a component of the MAPK pathway downstream of Olfr763. This disruption hinders the activation of transcription factors essential for Olfr763 expression, indirectly inhibiting the gene. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 inhibits the MAPK pathway downstream of Olfr763. This disruption hinders the activation of transcription factors necessary for Olfr763 expression, indirectly inhibiting the gene. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB inhibits Olfr763 by targeting intracellular calcium signaling. It modulates inositol trisphosphate receptors (IP3Rs), reducing calcium release and leading to decreased sensitivity of Olfr763 to odorant molecules, ultimately inhibiting its function. | ||||||