Olfr761 Inhibitors
Olfr761, a member of the olfactory receptor gene family in Mus musculus (house mouse), plays a fundamental role in the perception of odors. These olfactory receptors, which are G-protein-coupled receptors (GPCRs), are responsible for detecting and initiating neuronal responses upon interaction with odorant molecules. Their unique 7-transmembrane domain structure is shared with various neurotransmitter and hormone receptors, facilitating the recognition and transduction of odorant signals. The olfactory receptor gene family is the largest within the mouse genome, and their nomenclature is specific to this organism.
The inhibition of Olfr761 can be achieved through multiple mechanisms, primarily targeting crucial signaling pathways. These pathways include calcium channels, cAMP signaling, p38 MAPK pathway, ATP-gated P2X3 receptors, and intracellular calcium signaling. Additionally, certain inhibitors affect protein kinase A (PKA) and modulate inositol trisphosphate receptors (IP3Rs). By interfering with these pathways or processes, Olfr761's function is compromised, leading to reduced sensitivity to odorant molecules and ultimately inhibiting its role in smell perception. Understanding Olfr761 and its inhibition sheds light on the intricate processes governing olfaction in mice. These inhibitors offer valuable tools for research, allowing for a deeper investigation into the complexities of odorant signal transduction. Such studies can contribute to advancing our comprehension of olfactory receptor function and its regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF-96365 inhibits Olfr761 by blocking calcium channels, disrupting intracellular calcium signaling. This reduction in intracellular calcium levels leads to decreased sensitivity of Olfr761 to odorant molecules, ultimately inhibiting its function. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $93.00 $356.00 | 13 | |
SQ22536 indirectly inhibits Olfr761 by targeting the cAMP signaling pathway. It inhibits adenylate cyclase, reducing cAMP levels and disrupting the downstream activation of Olfr761, ultimately inhibiting the gene. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $30.00 $125.00 $445.00 | 45 | |
SB202190 inhibits p38 MAPK, a component of the MAPK pathway downstream of Olfr761. This disruption hinders the activation of transcription factors essential for Olfr761 expression, indirectly inhibiting the gene. | ||||||
NNC 55-0396 | 357400-13-6 | sc-203647A sc-203647 | 5 mg 10 mg | $245.00 $413.00 | 2 | |
NNC 55-0396 inhibits Olfr761 by targeting the ATP-gated P2X3 receptor, a crucial component in olfactory signal transduction. This blockade reduces downstream activation of Olfr761, inhibiting its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 inhibits the MAPK pathway downstream of Olfr761. This disruption hinders the activation of transcription factors necessary for Olfr761 expression, indirectly inhibiting the gene. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM inhibits Olfr761 by blocking intracellular calcium signaling. It is a cell-permeable calcium chelator that reduces calcium mobilization, leading to decreased sensitivity of Olfr761 to odorant molecules and inhibiting its function. | ||||||
SC514 | 354812-17-2 | sc-205504 sc-205504A | 5 mg 10 mg | $66.00 $89.00 | 13 | |
SC-514 inhibits p38 MAPK, a component of the MAPK pathway downstream of Olfr761. This disruption hinders the activation of transcription factors essential for Olfr761 expression, indirectly inhibiting the gene. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits the MAPK pathway downstream of Olfr761. This disruption hinders the activation of transcription factors necessary for Olfr761 expression, indirectly inhibiting the gene. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB inhibits Olfr761 by targeting intracellular calcium signaling. It modulates inositol trisphosphate receptors (IP3Rs), reducing calcium release and leading to decreased sensitivity of Olfr761 to odorant molecules, ultimately inhibiting its function. | ||||||