Olfr750 Inhibitors
Olfr750, an olfactory receptor gene found in Mus musculus (house mouse), plays a fundamental role in initiating the neuronal response responsible for the perception of odors. As a member of the G-protein-coupled receptor (GPCR) family, Olfr750 shares a 7-transmembrane domain structure with neurotransmitter and hormone receptors. Its function revolves around recognizing odorant molecules and mediating the transduction of odorant signals through G protein-mediated pathways. This gene belongs to the extensive olfactory receptor gene family, characterized by its unique nomenclature within the mouse genome.
Inhibition of Olfr750 can be accomplished through various mechanisms, including the targeting of signaling pathways critical to its function. These inhibitors impact the ATP-gated P2X3 receptor, cAMP signaling pathway, p38 MAPK pathway, and intracellular calcium signaling. Additionally, some inhibitors act as antagonists at metabotropic glutamate receptors and modulate calcium signaling, affecting olfactory signal amplification. By disrupting these pathways or processes, Olfr750's function is compromised, leading to reduced sensitivity to odorant molecules and ultimately inhibiting its role in smell perception. Understanding the inhibition of Olfr750 provides valuable insights into the intricate processes governing olfaction in mice. These inhibitors offer potential avenues for research to unravel the complexities of odorant signal transduction. Further studies in this area can enhance our comprehension of olfactory receptor function and its regulation, contributing to a deeper understanding of sensory perception in mice.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram indirectly inhibits Olfr750 by acting on the cAMP signaling pathway. It inhibits phosphodiesterase IV (PDE4), leading to increased cAMP levels, disrupting the downstream activation of Olfr750, ultimately inhibiting the gene. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 inhibits Olfr750 by targeting p38 MAPK, a component of the MAPK pathway downstream of Olfr750. This disruption hinders the activation of transcription factors necessary for Olfr750 expression, indirectly inhibiting the gene. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $21.00 $65.00 $120.00 $251.00 $815.00 | 23 | |
EGTA inhibits Olfr750 by blocking intracellular calcium signaling. It is a calcium chelator that reduces calcium mobilization, leading to decreased sensitivity of Olfr750 to odorant molecules and inhibiting its function. | ||||||
LY 341495 | 201943-63-7 | sc-361244 sc-361244A | 1 mg 10 mg | $89.00 $223.00 | 1 | |
LY341495 acts as an antagonist at metabotropic glutamate receptors, affecting olfactory signal transduction. It leads to reduced activation of Olfr750 and inhibition of its function. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine inhibits Olfr750 by blocking calcium channels, disrupting intracellular calcium signaling. This reduces Olfr750 sensitivity to odorant molecules, ultimately inhibiting its function. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM inhibits Olfr750 by blocking intracellular calcium signaling. It is a cell-permeable calcium chelator that reduces calcium mobilization, leading to decreased sensitivity of Olfr750 to odorant molecules and inhibiting its function. | ||||||
MPEP hydrochloride | 96206-92-7 | sc-279454A sc-279454 | 10 mg 50 mg | $136.00 $520.00 | ||
MPEP acts as an antagonist at metabotropic glutamate receptors, affecting olfactory signal transduction. It leads to reduced activation of Olfr750 and inhibition of its function. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits Olfr750 by disrupting intracellular calcium signaling. It specifically targets the endoplasmic reticulum calcium ATPase (SERCA), leading to decreased sensitivity of Olfr750 to odorant molecules and inhibiting its function. | ||||||